Literature DB >> 27722205

Modeling Cancer with Pluripotent Stem Cells.

Julian Gingold1, Ruoji Zhou2, Ihor R Lemischka3, Dung-Fang Lee4.   

Abstract

The elucidation of cancer pathogenesis has been hindered by limited access to patient samples, tumor heterogeneity and the lack of reliable model organisms. Characterized by their ability to self-renew indefinitely and differentiate into all cell lineages of an organism, pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), provide a powerful and unlimited source to generate differentiated cells that can be used to study disease biology, facilitate drug discovery and development, and provide key insights for developing personalized therapies. This article reviews the recent developments and technologies converting PSCs into clinically relevant model systems for cancer research.

Entities:  

Keywords:  Cancer Disease Modeling; Differentiation; Genome Editing; Pluripotent Stem Cells

Mesh：

Year:  2016        PMID： 27722205      PMCID： PMC5050918          DOI： 10.1016/j.trecan.2016.07.007

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  95 in total

1.  Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney.

Authors:  M Takasato; P X Er; M Becroft; J M Vanslambrouck; E G Stanley; A G Elefanty; M H Little
Journal:  Nat Cell Biol       Date:  2013-12-15       Impact factor: 28.824

2.  KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.

Authors:  Orit Goldman; Songyan Han; Marion Sourisseau; Marion Sourrisseau; Noelle Dziedzic; Wissam Hamou; Barbara Corneo; Sunita D'Souza; Thomas Sato; Darrell N Kotton; Karl-Dimiter Bissig; Tamara Kalir; Adam Jacobs; Todd Evans; Matthew J Evans; Valerie Gouon-Evans
Journal:  Cell Stem Cell       Date:  2013-06-06       Impact factor: 24.633

3.  Modeling familial Alzheimer's disease with induced pluripotent stem cells.

Authors:  Takuya Yagi; Daisuke Ito; Yohei Okada; Wado Akamatsu; Yoshihiro Nihei; Takahito Yoshizaki; Shinya Yamanaka; Hideyuki Okano; Norihiro Suzuki
Journal:  Hum Mol Genet       Date:  2011-09-07       Impact factor: 6.150

Review 4.  Engineering Stem Cell Organoids.

Authors:  Xiaolei Yin; Benjamin E Mead; Helia Safaee; Robert Langer; Jeffrey M Karp; Oren Levy
Journal:  Cell Stem Cell       Date:  2016-01-07       Impact factor: 24.633

5.  Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells.

Authors:  Agamemnon E Grigoriadis; Marion Kennedy; Aline Bozec; Fiona Brunton; Gudrun Stenbeck; In-Hyun Park; Erwin F Wagner; Gordon M Keller
Journal:  Blood       Date:  2010-01-11       Impact factor: 22.113

6.  Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells.

Authors:  Kosuke Yusa; S Tamir Rashid; Helene Strick-Marchand; Ignacio Varela; Pei-Qi Liu; David E Paschon; Elena Miranda; Adriana Ordóñez; Nicholas R F Hannan; Foad J Rouhani; Sylvie Darche; Graeme Alexander; Stefan J Marciniak; Noemi Fusaki; Mamoru Hasegawa; Michael C Holmes; James P Di Santo; David A Lomas; Allan Bradley; Ludovic Vallier
Journal:  Nature       Date:  2011-10-12       Impact factor: 49.962

7.  Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.

Authors:  Luis F Z Batista; Matthew F Pech; Franklin L Zhong; Ha Nam Nguyen; Kathleen T Xie; Arthur J Zaug; Sharon M Crary; Jinkuk Choi; Vittorio Sebastiano; Athena Cherry; Neelam Giri; Marius Wernig; Blanche P Alter; Thomas R Cech; Sharon A Savage; Renee A Reijo Pera; Steven E Artandi
Journal:  Nature       Date:  2011-05-22       Impact factor: 49.962

8.  Modelling human development and disease in pluripotent stem-cell-derived gastric organoids.

Authors:  Kyle W McCracken; Emily M Catá; Calyn M Crawford; Katie L Sinagoga; Michael Schumacher; Briana E Rockich; Yu-Hwai Tsai; Christopher N Mayhew; Jason R Spence; Yana Zavros; James M Wells
Journal:  Nature       Date:  2014-10-29       Impact factor: 49.962

9.  Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.

Authors:  Milena Bellin; Simona Casini; Richard P Davis; Cristina D'Aniello; Jessica Haas; Dorien Ward-van Oostwaard; Leon G J Tertoolen; Christian B Jung; David A Elliott; Andrea Welling; Karl-Ludwig Laugwitz; Alessandra Moretti; Christine L Mummery
Journal:  EMBO J       Date:  2013-11-08       Impact factor: 11.598

10.  Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac.

Authors:  Fei Xie; Lin Ye; Judy C Chang; Ashley I Beyer; Jiaming Wang; Marcus O Muench; Yuet Wai Kan
Journal:  Genome Res       Date:  2014-08-05       Impact factor: 9.043
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  12 in total

Review 1.  Osteosarcoma: Molecular Pathogenesis and iPSC Modeling.

Authors:  Yu-Hsuan Lin; Brittany E Jewell; Julian Gingold; Linchao Lu; Ruiying Zhao; Lisa L Wang; Dung-Fang Lee
Journal:  Trends Mol Med       Date:  2017-07-20       Impact factor: 11.951

Review 2.  Li-Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53.

Authors:  Ruoji Zhou; An Xu; Julian Gingold; Louise C Strong; Ruiying Zhao; Dung-Fang Lee
Journal:  Trends Pharmacol Sci       Date:  2017-08-14       Impact factor: 14.819

3.  Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells.

Authors:  Ruoji Zhou; An Xu; Jian Tu; Mo Liu; Julian A Gingold; Ruiying Zhao; Dung-Fang Lee
Journal:  J Vis Exp       Date:  2018-06-13       Impact factor: 1.355

Review 4.  Cancer in a dish: progress using stem cells as a platform for cancer research.

Authors:  Mo Liu; Jian Tu; Julian A Gingold; Celine Shuet Lin Kong; Dung-Fang Lee
Journal:  Am J Cancer Res       Date:  2018-06-01       Impact factor: 6.166

5.  Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism.

Authors:  Huensuk Kim; Seungyeul Yoo; Ruoji Zhou; An Xu; Jeffrey M Bernitz; Ye Yuan; Andreia M Gomes; Michael G Daniel; Jie Su; Elizabeth G Demicco; Jun Zhu; Kateri A Moore; Dung-Fang Lee; Ihor R Lemischka; Christoph Schaniel
Journal:  Proc Natl Acad Sci U S A       Date:  2018-11-01       Impact factor: 11.205

6.  Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing.

Authors:  An Xu; Ruoji Zhou; Jian Tu; Zijun Huo; Dandan Zhu; Donghui Wang; Julian A Gingold; Helen Mata; Pulivarthi H Rao; Mo Liu; Alaa M T Mohamed; Celine Shuet Lin Kong; Brittany E Jewell; Weiya Xia; Ruiying Zhao; Mien-Chie Hung; Dung-Fang Lee
Journal:  Stem Cell Res       Date:  2018-04-27       Impact factor: 2.020

7.  Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner.

Authors:  Ralitsa R Madsen; Rachel G Knox; Wayne Pearce; Saioa Lopez; Betania Mahler-Araujo; Nicholas McGranahan; Bart Vanhaesebroeck; Robert K Semple
Journal:  Proc Natl Acad Sci U S A       Date:  2019-04-04       Impact factor: 11.205

8.  Development of Functional Thyroid C Cell-like Cells from Human Pluripotent Cells in 2D and in 3D Scaffolds.

Authors:  Kwaku Dad Abu-Bonsrah; Donald F Newgreen; Mirella Dottori
Journal:  Cells       Date:  2021-10-26       Impact factor: 6.600

Review 9.  Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications.

Authors:  Michael Xavier Doss; Agapios Sachinidis
Journal:  Cells       Date:  2019-04-30       Impact factor: 6.600

10.  Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy.

Authors:  Matko Čančer; Sonja Hutter; Karl O Holmberg; Gabriela Rosén; Anders Sundström; Jignesh Tailor; Tobias Bergström; Alexandra Garancher; Magnus Essand; Robert J Wechsler-Reya; Anna Falk; Holger Weishaupt; Fredrik J Swartling
Journal:  Cell Stem Cell       Date:  2019-11-27       Impact factor: 24.633
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