Omer Karti1, Ozlem Nalbantoglu2, Saygin Abali3, Selma Tunc2, Behzat Ozkan2. 1. Department of Ophthalmology, Bozyaka Training and Research Hospital, Saim Çıkrıkçı cad. no: 59 Bozyaka, Izmir, Turkey. omer.karti@deu.edu.tr. 2. Department of Pediatrics, Pediatric Endocrinology, Behcet Uz Training and Research Hospital, Izmir, Turkey. 3. Department of Pediatrics, Pediatric Endocrinology, Dr. Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey.
Abstract
PURPOSE: To investigate the relationship between the obesity and optical coherence tomography (OCT) parameters. METHODS: We studied 54 obese and 33 non-obese children and adolescents. Obesity was defined as BMI higher than 95th percentile (BMI SDS > 1.64). OCT measurements were performed in all participants. Anthropometric and biochemical variables were compared with OCT parameters of 174 eyes. RESULTS: In obese children, in all quadrants retinal nerve fiber layer (RNFL) thicknesses were significantly lower than non-obese children, and also ganglion cell-inner plexiform layer thicknesses in inferior and superiortemporal quadrants were significantly lower in the obese group. BMI SDS, insulin, HOMA-IR and triglyceride levels were negatively correlated with RNFL thickness, significantly (r = -0.386, p < 0.001; r = -0.229, p = 0.002; r = -0.188, p = 0.013; and r = -0.301, p = 0.000; respectively) in all subjects. CONCLUSIONS: Thinning in RNFL was detected in normal-looking discs of obese children, and this thinning negatively correlated with BMI SDS. Further studies including large series are needed to clarify whether obesity has an effect on RNFL thickness.
PURPOSE: To investigate the relationship between the obesity and optical coherence tomography (OCT) parameters. METHODS: We studied 54 obese and 33 non-obesechildren and adolescents. Obesity was defined as BMI higher than 95th percentile (BMI SDS > 1.64). OCT measurements were performed in all participants. Anthropometric and biochemical variables were compared with OCT parameters of 174 eyes. RESULTS: In obesechildren, in all quadrants retinal nerve fiber layer (RNFL) thicknesses were significantly lower than non-obesechildren, and also ganglion cell-inner plexiform layer thicknesses in inferior and superiortemporal quadrants were significantly lower in the obese group. BMI SDS, insulin, HOMA-IR and triglyceride levels were negatively correlated with RNFL thickness, significantly (r = -0.386, p < 0.001; r = -0.229, p = 0.002; r = -0.188, p = 0.013; and r = -0.301, p = 0.000; respectively) in all subjects. CONCLUSIONS: Thinning in RNFL was detected in normal-looking discs of obesechildren, and this thinning negatively correlated with BMI SDS. Further studies including large series are needed to clarify whether obesity has an effect on RNFL thickness.
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Authors: Y Arita; S Kihara; N Ouchi; M Takahashi; K Maeda; J Miyagawa; K Hotta; I Shimomura; T Nakamura; K Miyaoka; H Kuriyama; M Nishida; S Yamashita; K Okubo; K Matsubara; M Muraguchi; Y Ohmoto; T Funahashi; Y Matsuzawa Journal: Biochem Biophys Res Commun Date: 1999-04-02 Impact factor: 3.575
Authors: R V Considine; M K Sinha; M L Heiman; A Kriauciunas; T W Stephens; M R Nyce; J P Ohannesian; C C Marco; L J McKee; T L Bauer Journal: N Engl J Med Date: 1996-02-01 Impact factor: 91.245