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Literature DB >> 27717163

Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces.

Tao Yu^1,2, Jane Chisholm^1,3, Woo Jin Choi², Abraham Anonuevo³, Sarah Pulicare³, Weixi Zhong², Minmin Chen¹, Colleen Fridley³, Samuel K Lai⁴, Laura M Ensign^1,3,5, Jung Soo Suk^1,5, Justin Hanes^1,2,3,5.

Abstract

Mucus-penetrating nanosuspensions, consisting of pure hydrophobic therapeutics with dense muco-inert coatings that enable particles to effectively bypass the mucus barrier, demonstrate superior drug distribution and absorption at mucosal surfaces. With significantly increased drug load compared to polymeric systems and established clinical translation of nanosuspensions-based products, mucus-penetrating nanosuspensions are a promising vehicle for improving mucosal delivery of poorly soluble drugs.

Entities: Chemical Disease Gene Species

Keywords: curcumin; drug delivery; mucus penetrating particles; nanocrystals; nanotechnology

Mesh：

Substances：

Year: 2016 PMID： 27717163 PMCID： PMC5586074 DOI： 10.1002/adhm.201600599

Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933

50 in total

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10 in total

1. Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease.

Authors: Abhijit A Date; Gilad Halpert; Taarika Babu; Jairo Ortiz; Pranjali Kanvinde; Peter Dimitrion; Janani Narayan; Hannah Zierden; Kalpana Betageri; Olivia Musmanno; Helen Wiegand; Xinglu Huang; Sanjeev Gumber; Justin Hanes; Laura M Ensign
Journal: Biomaterials Date: 2018-09-07 Impact factor: 12.479

2. Tuning the PEG surface density of the PEG-PGA enveloped Octaarginine-peptide Nanocomplexes.

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Authors: Mahboubeh S Noori; Sarah J Bodle; Christian A Showalter; Evan S Streator; David S Drozek; Monica M Burdick; Douglas J Goetz
Journal: Cell Mol Bioeng Date: 2020-01-21 Impact factor: 2.321

4. Development of a mucoinert progesterone nanosuspension for safer and more effective prevention of preterm birth.

Authors: Thuy Hoang; Hannah Zierden; Abhijit Date; Jairo Ortiz; Sanjeev Gumber; Nicole Anders; Ping He; James Segars; Justin Hanes; Mala Mahendroo; Laura M Ensign
Journal: J Control Release Date: 2018-12-28 Impact factor: 9.776

5. Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth.

Authors: Hannah C Zierden; Jairo I Ortiz; Kevin DeLong; Jingqi Yu; Gaoshan Li; Peter Dimitrion; Sabrine Bensouda; Victoria Laney; Anna Bailey; Nicole M Anders; Morgan Scardina; Mala Mahendroo; Sam Mesiano; Irina Burd; Gunter Wagner; Justin Hanes; Laura M Ensign
Journal: Sci Transl Med Date: 2021-01-13 Impact factor: 17.956