Sunila Shakya1,2, Unni Syversen3,4, Bjørn O Åsvold4,5, Anna M Bofin1, Guro Aune1,6, Svein A Nordbø1,7, Karishma M Vaidya8, Biraj M Karmacharya9, Jan E Afset1,7, Solveig Tingulstad1,6. 1. Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. 2. Department of Gynecology and Obstetrics, Dhulikhel Hospital/Kathmandu University School of Medical Sciences, Kavre, Nepal. 3. Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. 4. Department of Endocrinology, St Olav's Hospital, Trondheim, Norway. 5. Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. 6. Department of Obstetrics and Gynecology, St Olav's Hospital, Trondheim, Norway. 7. Department of Microbiology, St Olav's Hospital, Trondheim, Norway. 8. Paropakar Maternity and Women's Hospital, Kathmandu, Nepal. 9. Department of Community Medicine, Dhulikhel Hospital/Kathmandu University School of Medical Sciences, Kavre, Nepal.
Abstract
INTRODUCTION: In this study we aimed to determine the overall and type-specific prevalence of cervical human papillomavirus (HPV) infection and risk factors for such infection among women in rural Nepal, and to investigate the distribution of HPV infection by cervical cytology. MATERIAL AND METHODS: The study was conducted among women aged ≥15 years in five rural villages within Kavre District in Nepal. Sociodemographic data and information on risk factors for cervical cancer were obtained through an interview, and a cervical specimen was collected for HPV DNA detection and typing using the Anyplex™ ll HPV28 Detection system, and for Papanicolaou test. RESULTS: Among the 1289 women in whom a valid HPV result was obtained the median age was 40 years (range 17-86 years). Overall, the HPV prevalence was 14.4%, 7.9% for high-risk and 6.5% for low-risk HPV types, and was similar between age groups. The five most common HR types were HPV-18 (2.3%), HPV-51 (1.2%), HPV-59 (1.1%), HPV-31 (0.9%), and HPV-16 (0.8%). The prevalence of high-risk types in women with and without abnormal cytology was 8.3 and 7.7%, respectively. HPV infection was associated with current smoking, formal education, and being married to a husband with at least one previous marriage. CONCLUSIONS: This is the first population-based study to report the prevalence of a broad range of HPV types among women from rural Nepal. These data are crucial for development of preventive strategies to reduce cervical cancer burden in the country.
INTRODUCTION: In this study we aimed to determine the overall and type-specific prevalence of cervical human papillomavirus (HPV) infection and risk factors for such infection among women in rural Nepal, and to investigate the distribution of HPV infection by cervical cytology. MATERIAL AND METHODS: The study was conducted among women aged ≥15 years in five rural villages within Kavre District in Nepal. Sociodemographic data and information on risk factors for cervical cancer were obtained through an interview, and a cervical specimen was collected for HPV DNA detection and typing using the Anyplex™ ll HPV28 Detection system, and for Papanicolaou test. RESULTS: Among the 1289 women in whom a valid HPV result was obtained the median age was 40 years (range 17-86 years). Overall, the HPV prevalence was 14.4%, 7.9% for high-risk and 6.5% for low-risk HPV types, and was similar between age groups. The five most common HR types were HPV-18 (2.3%), HPV-51 (1.2%), HPV-59 (1.1%), HPV-31 (0.9%), and HPV-16 (0.8%). The prevalence of high-risk types in women with and without abnormal cytology was 8.3 and 7.7%, respectively. HPV infection was associated with current smoking, formal education, and being married to a husband with at least one previous marriage. CONCLUSIONS: This is the first population-based study to report the prevalence of a broad range of HPV types among women from rural Nepal. These data are crucial for development of preventive strategies to reduce cervical cancer burden in the country.
Authors: Chandra Yogal; Sunila Shakya; Biraj Karmarcharya; Rajendra Koju; Astrid Kamilla Stunes; Mats Peder Mosti; Miriam K Gustafsson; Bjørn Olav Åsvold; Berit Schei; Unni Syversen Journal: Int J Environ Res Public Health Date: 2022-06-08 Impact factor: 4.614
Authors: Sunila Shakya; Solveig Thingulstad; Unni Syversen; Svein Arne Nordbø; Surendra Madhup; Krista Vaidya; Biraj Man Karmacharya; Bjørn Olav Åsvold; Jan Egil Afset Journal: Infect Dis Obstet Gynecol Date: 2018-08-26