| Literature DB >> 27714209 |
Munmun Maiti1, Ling-Jie Gao1, Chunsheng Huang2, Roger G Ptak2, Michael G Murray2, Steven De Jonghe1, Piet Herdewijn1.
Abstract
In an attempt to identify novel nucleoside phosphoramidate analogues for improving the anti-HCV activity of 2'-C-Me-uridine, we have synthesized for the first time a series of l-glutamic acid, l-serine, l-threonine and l-tyrosine containing aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine. Evaluation of their activity against HCV revealed that they displayed very potent anti-HCV activity, with EC50 values that are in the same range as of Sofosbuvir.Entities:
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Year: 2016 PMID： 27714209 PMCID： PMC5079539 DOI： 10.1039/c6ob01189f
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876