Literature DB >> 27711349

Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition.

Matthew Huisman1, Jessica K White2, Veronica G Lewalski1, Izabela Podgorski3, Claudia Turro2, Jeremy J Kodanko4.   

Abstract

Photochemical control over irreversible inhibition was shown using Ru(ii)-caged inhibitors of cathepsin L. Levels of control were dependent on where the Ru(ii) complex was attached to the organic inhibitor, reaching >10 : 1 with optimal placement. A new strategy for photoreleasing Ru(ii) fragments from inhibitor-enzyme conjugates is also reported.

Entities:  

Year:  2016        PMID： 27711349      PMCID： PMC5076553          DOI： 10.1039/c6cc07083c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  23 in total

Review 1.  Cathepsins and their involvement in immune responses.

Authors:  Sébastien Conus; Hans-Uwe Simon
Journal:  Swiss Med Wkly       Date:  2010-07-20       Impact factor: 2.193

Review 2.  Cathepsin L targeting in cancer treatment.

Authors:  Dhivya R Sudhan; Dietmar W Siemann
Journal:  Pharmacol Ther       Date:  2015-08-20       Impact factor: 12.310

Review 3.  Development of nitrile-based peptidic inhibitors of cysteine cathepsins.

Authors:  Maxim Frizler; Marit Stirnberg; Mihiret Tekeste Sisay; Michael Gütschow
Journal:  Curr Top Med Chem       Date:  2010       Impact factor: 3.295

Review 4.  The resurgence of covalent drugs.

Authors:  Juswinder Singh; Russell C Petter; Thomas A Baillie; Adrian Whitty
Journal:  Nat Rev Drug Discov       Date:  2011-04       Impact factor: 84.694

5.  Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine.

Authors:  Nicola J Farrer; Luca Salassa; Peter J Sadler
Journal:  Dalton Trans       Date:  2009-11-11       Impact factor: 4.390

6.  Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase.

Authors:  P Kuzmic
Journal:  Anal Biochem       Date:  1996-06-01       Impact factor: 3.365

Review 7.  Photoremovable protecting groups in chemistry and biology: reaction mechanisms and efficacy.

Authors:  Petr Klán; Tomáš Šolomek; Christian G Bochet; Aurélien Blanc; Richard Givens; Marina Rubina; Vladimir Popik; Alexey Kostikov; Jakob Wirz
Journal:  Chem Rev       Date:  2012-12-21       Impact factor: 60.622

8.  Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis.

Authors:  Wei Li; Louise Kornmark; Lena Jonasson; Claes Forssell; Xi-Ming Yuan
Journal:  Atherosclerosis       Date:  2008-04-18       Impact factor: 5.162

9.  Design strategies to improve the sensitivity of photoactive metal carbonyl complexes (photoCORMs) to visible light and their potential as CO-donors to biological targets.

Authors:  Indranil Chakraborty; Samantha J Carrington; Pradip K Mascharak
Journal:  Acc Chem Res       Date:  2014-07-08       Impact factor: 22.384

10.  Unusually efficient pyridine photodissociation from Ru(II) complexes with sterically bulky bidentate ancillary ligands.

Authors:  Jessica D Knoll; Bryan A Albani; Christopher B Durr; Claudia Turro
Journal:  J Phys Chem A       Date:  2014-07-25       Impact factor: 2.781
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  18 in total

1.  Photoactivation of imatinib-antibody conjugate using low-energy visible light from Ru(ii)-polypyridyl cages.

Authors:  Thomas N Rohrabaugh; Ashley M Rohrabaugh; Jeremy J Kodanko; Jessica K White; Claudia Turro
Journal:  Chem Commun (Camb)       Date:  2018-05-17       Impact factor: 6.222

2.  Affinity-Enhanced Luminescent Re(I)- and Ru(II)-Based Inhibitors of the Cysteine Protease Cathepsin L.

Authors:  Matthew Huisman; Jacob P Kodanko; Karan Arora; Mackenzie Herroon; Marim Alnaed; John Endicott; Izabela Podgorski; Jeremy J Kodanko
Journal:  Inorg Chem       Date:  2018-06-08       Impact factor: 5.165

3.  Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.

Authors:  Roy Weinstain; Tomáš Slanina; Dnyaneshwar Kand; Petr Klán
Journal:  Chem Rev       Date:  2020-10-30       Impact factor: 60.622

4.  Ru(ii) polypyridyl complexes as photocages for bioactive compounds containing nitriles and aromatic heterocycles.

Authors:  Ao Li; Claudia Turro; Jeremy J Kodanko
Journal:  Chem Commun (Camb)       Date:  2018-02-01       Impact factor: 6.222

5.  DFT Investigation of Ligand Photodissociation in [RuII(tpy)(bpy)(py)]2+ and [RuII(tpy)(Me2bpy)(py)]2+ Complexes.

Authors:  Khalin Nisbett; Yi-Jung Tu; Claudia Turro; Jeremy J Kodanko; H Bernhard Schlegel
Journal:  Inorg Chem       Date:  2017-12-19       Impact factor: 5.165

6.  Ru(II) Polypyridyl Complexes Derived from Tetradentate Ancillary Ligands for Effective Photocaging.

Authors:  Ao Li; Claudia Turro; Jeremy J Kodanko
Journal:  Acc Chem Res       Date:  2018-06-05       Impact factor: 22.384

7.  Catch and Release Photosensitizers: Combining Dual-Action Ruthenium Complexes with Protease Inactivation for Targeting Invasive Cancers.

Authors:  Karan Arora; Mackenzie Herroon; Malik H Al-Afyouni; Nicholas P Toupin; Thomas N Rohrabaugh; Lauren M Loftus; Izabela Podgorski; Claudia Turro; Jeremy J Kodanko
Journal:  J Am Chem Soc       Date:  2018-10-22       Impact factor: 15.419

8.  Ru(ii) complexes with diazine ligands: electronic modulation of the coordinating group is key to the design of "dual action" photoactivated agents.

Authors:  Dmytro Havrylyuk; Megha Deshpande; Sean Parkin; Edith C Glazer
Journal:  Chem Commun (Camb)       Date:  2018-11-01       Impact factor: 6.222

9.  Singlet Oxygen Formation vs Photodissociation for Light-Responsive Protic Ruthenium Anticancer Compounds: The Oxygenated Substituent Determines Which Pathway Dominates.

Authors:  Fengrui Qu; Robert W Lamb; Colin G Cameron; Seungjo Park; Olaitan Oladipupo; Jessica L Gray; Yifei Xu; Houston D Cole; Marco Bonizzoni; Yonghyun Kim; Sherri A McFarland; Charles Edwin Webster; Elizabeth T Papish
Journal:  Inorg Chem       Date:  2021-02-03       Impact factor: 5.165

10.  Photorelease of a metal-binding pharmacophore from a Ru(II) polypyridine complex.

Authors:  Johannes Karges; Ryjul W Stokes; Seth M Cohen
Journal:  Dalton Trans       Date:  2021-03-02       Impact factor: 4.390
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