Literature DB >> 27703035

CD4+ T Cells Coexpressing CD134 (OX40) Harbor Significantly Increased Levels of Human Herpesvirus 6B DNA Following Umbilical Cord Blood Transplantation.

Joshua C Pritchett1, Jaime S Green2, Angela M Thomm3, Konstance K Knox3, Michael R Verneris1, Troy C Lund1.   

Abstract

Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dysfunction. Recently, CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4+CD134+/neg-lo and CD8+CD134+/neg-lo cells at day 28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Analysis of CD4+CD134+ cells as compared to CD4+CD134neg-lo cells showed 0.308 versus 0.129 copies of HHV-6B/cell (P = .0002). CD8+CD134+/neg-lo cells contained little to no HHV-6B copies. Following UCBT, CD4+CD134+ cells harbor significantly increased levels of HHV-6B, suggesting that CD134 (OX40) may facilitate viral entry.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Entities:  

Keywords:  CD134; HHV-6; OX40; herpesvirus; umbilical cord blood transplantation

Mesh：

Substances：

Year:  2016        PMID： 27703035      PMCID： PMC5142091          DOI： 10.1093/infdis/jiw469

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

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4.  Early human herpes virus type 6 reactivation in umbilical cord blood allogeneic stem cell transplantation.

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7.  Long-lasting HHV-6 reactivation in long-term adult survivors after double umbilical cord blood allogeneic stem cell transplantation.

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Review 8.  Roseoloviruses in transplant recipients: clinical consequences and prospects for treatment and prevention trials.

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Journal:  Rev Med Virol       Date:  2011-11-04       Impact factor: 6.989

10.  Characterization of HIV-1 entry inhibitors with broad activity against R5 and X4 viral strains.

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Journal:  J Transl Med       Date:  2015-04-02       Impact factor: 5.531
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Journal:  J Virol       Date:  2020-02-28       Impact factor: 5.103
  1 in total

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