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Literature DB >> 27699107

Dual-modality endomicroscopy with co-registered fluorescence and phase contrast.

Abstract

We describe a dual-modality laser scanning endomicroscope that provides simultaneous fluorescence contrast based on confocal laser endomicroscopy (CLE) and phase-gradient contrast based on scanning oblique back-scattering microscopy (sOBM). The probe consists of a 2.6mm-diameter micro-objective attached to a 30,000-core flexible fiber bundle. The dual contrasts are inherently co-registered, providing complementary information on labeled and un-labeled sample structure. Proof of principle demonstrations are presented with ex-vivo mouse colon tissue.

Entities: Species

Keywords: (120.5050) Phase measurement; (170.1790) Confocal microscopy; (170.2150) Endoscopic imaging; (180.5810) Scanning microscopy

Year: 2016 PMID： 27699107 PMCID： PMC5030019 DOI： 10.1364/BOE.7.003403

Source DB: PubMed Journal: Biomed Opt Express ISSN： 2156-7085 Impact factor: 3.732

35 in total

1. Fast optically sectioned fluorescence HiLo endomicroscopy.

Authors: Tim N Ford; Daryl Lim; Jerome Mertz
Journal: J Biomed Opt Date: 2012-02 Impact factor: 3.170

2. Quantitative phase imaging via Fourier ptychographic microscopy.

Authors: Xiaoze Ou; Roarke Horstmeyer; Changhuei Yang; Guoan Zheng
Journal: Opt Lett Date: 2013-11-15 Impact factor: 3.776

3. Video-rate imaging of microcirculation with single-exposure oblique back-illumination microscopy.

Authors: Tim N Ford; Jerome Mertz
Journal: J Biomed Opt Date: 2013-06 Impact factor: 3.170

4. Quantitative phase imaging using a partitioned detection aperture.

Authors: Ashwin B Parthasarathy; Kengyeh K Chu; Tim N Ford; Jerome Mertz
Journal: Opt Lett Date: 2012-10-01 Impact factor: 3.776

5. Integrated multimodal endomicroscopy platform for simultaneous en face optical coherence and two-photon fluorescence imaging.

Authors: Jiefeng Xi; Yongping Chen; Yuying Zhang; Kartikeya Murari; Ming-Jun Li; Xingde Li
Journal: Opt Lett Date: 2012-02-01 Impact factor: 3.776

6. Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model.

Authors: Lida P Hariri; Alexandre R Tumlinson; David G Besselsen; Urs Utzinger; Eugene W Gerner; Jennifer K Barton
Journal: Lasers Surg Med Date: 2006-04 Impact factor: 4.025

7. Diagnostic potential of multimodal imaging of ovarian tissue using optical coherence tomography and second-harmonic generation microscopy.

Authors: Weston A Welge; Andrew T DeMarco; Jennifer M Watson; Photini S Rice; Jennifer K Barton; Matthew A Kupinski
Journal: J Med Imaging (Bellingham) Date: 2014-07-18

Dual-modality endomicroscopy with co-registered fluorescence and phase contrast.

1. Fast optically sectioned fluorescence HiLo endomicroscopy.

2. Quantitative phase imaging via Fourier ptychographic microscopy.

3. Video-rate imaging of microcirculation with single-exposure oblique back-illumination microscopy.

4. Quantitative phase imaging using a partitioned detection aperture.

5. Integrated multimodal endomicroscopy platform for simultaneous en face optical coherence and two-photon fluorescence imaging.

6. Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model.

7. Diagnostic potential of multimodal imaging of ovarian tissue using optical coherence tomography and second-harmonic generation microscopy.

8. Compensation-free, all-fiber-optic, two-photon endomicroscopy at 1.55 μm.

9. Subcellular-resolution molecular imaging within living tissue by fiber microendoscopy.

10. Phase-gradient microscopy in thick tissue with oblique back-illumination.

1. Reconstruction of Optical Vector-Fields With Applications in Endoscopic Imaging.

2. Fast hyperspectral phase and amplitude imaging in scattering tissue.