| Literature DB >> 27697546 |
Wei Cai1, Kai Zhang2, Peiying Li3, Ling Zhu4, Jing Xu2, Boyu Yang2, Xiaoming Hu2, Zhengqi Lu5, Jun Chen6.
Abstract
Current understanding on the mechanisms of brain injury and neurodegeneration highlights an appreciation of multicellular interactions within the neurovascular unit (NVU), which include the evolution of blood-brain barrier (BBB) damage, neuronal cell death or degeneration, glial reaction, and immune cell infiltration. Aging is an important factor that influences the integrity of the NVU. The age-related physiological or pathological changes in the cellular components of the NVU have been shown to increase the vulnerability of the NVU to ischemia/reperfusion injury or neurodegeneration, and to result in deteriorated brain damage. This review describes the impacts of aging on each NVU component and discusses the mechanisms by which aging increases NVU sensitivity to stroke and neurodegenerative diseases. Prophylactic or therapeutic perspectives that may delay or diminish aging and thus prevent the incidence of these neurological disorders will also be reviewed.Entities:
Keywords: Aging; Ischemic stroke; Neurodegeneration; Neurovascular unit; Vulnerability
Mesh：
Year: 2016 PMID： 27697546 PMCID： PMC5384332 DOI： 10.1016/j.arr.2016.09.006
Source DB: PubMed Journal: Ageing Res Rev ISSN： 1568-1637 Impact factor: 10.895