Literature DB >> 32854855

Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases.

Erin O Wissler Gerdes1, Yi Zhu1, B Melanie Weigand1, Utkarsh Tripathi1, Terence C Burns1, Tamar Tchkonia1, James L Kirkland2.   

Abstract

Aging is the major predictor for developing multiple neurodegenerative diseases, including Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells, which can drive aging phenotypes, accumulate at etiological sites of many age-related chronic diseases. These cells are resistant to apoptosis and can cause local and systemic dysfunction. Decreasing senescent cell abundance using senolytic drugs, agents that selectively target these cells, alleviates neurodegenerative diseases in preclinical models. In this review, we consider roles of senescent cells in neurodegenerative diseases and potential implications of senolytic agents as an innovative treatment.
© 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; Cellular senescence; Dasatinib; Fisetin; Navitoclax; Parkinson's disease; Quercetin; Senescence-associated secretory phenotype; Senescent cell anti-apoptotic pathways; Senolytics

Year:  2020        PMID： 32854855      PMCID： PMC7656525          DOI： 10.1016/bs.irn.2020.03.019

Source DB:  PubMed          Journal:  Int Rev Neurobiol        ISSN： 0074-7742            Impact factor:   3.230


  164 in total

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Journal:  J Neurol       Date:  2000-04       Impact factor: 4.849

2.  Pathological correlates of dementia in a longitudinal, population-based sample of aging.

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Review 3.  Pharmacological treatment of Parkinson disease: a review.

Authors:  Barbara S Connolly; Anthony E Lang
Journal:  JAMA       Date:  2014 Apr 23-30       Impact factor: 56.272

4.  Non-motor features of Parkinson disease.

Authors:  Anthony H V Schapira; K Ray Chaudhuri; Peter Jenner
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5.  Identification of Senescent Cells in the Bone Microenvironment.

Authors:  Joshua N Farr; Daniel G Fraser; Haitao Wang; Katharina Jaehn; Mikolaj B Ogrodnik; Megan M Weivoda; Matthew T Drake; Tamara Tchkonia; Nathan K LeBrasseur; James L Kirkland; Lynda F Bonewald; Robert J Pignolo; David G Monroe; Sundeep Khosla
Journal:  J Bone Miner Res       Date:  2016-10-24       Impact factor: 6.741

Review 6.  Calcium homeostasis, selective vulnerability and Parkinson's disease.

Authors:  C Savio Chan; Tracy S Gertler; D James Surmeier
Journal:  Trends Neurosci       Date:  2009-03-21       Impact factor: 13.837

Review 7.  Cognitive effects of cancer and its treatments at the intersection of aging: what do we know; what do we need to know?

Authors:  Jeanne S Mandelblatt; Arti Hurria; Brenna C McDonald; Andrew J Saykin; Robert A Stern; John W VanMeter; Meghan McGuckin; Tiffani Traina; Neelima Denduluri; Scott Turner; Darlene Howard; Paul B Jacobsen; Tim Ahles
Journal:  Semin Oncol       Date:  2013-12       Impact factor: 4.929

Review 8.  Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.

Authors:  Allyson K Palmer; Tamara Tchkonia; Nathan K LeBrasseur; Eduardo N Chini; Ming Xu; James L Kirkland
Journal:  Diabetes       Date:  2015-07       Impact factor: 9.461

Review 9.  Cellular senescence: at the nexus between ageing and diabetes.

Authors:  Allyson K Palmer; Birgit Gustafson; James L Kirkland; Ulf Smith
Journal:  Diabetologia       Date:  2019-08-27       Impact factor: 10.122

10.  Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response.

Authors:  Diana Jurk; Chunfang Wang; Satomi Miwa; Mandy Maddick; Viktor Korolchuk; Avgi Tsolou; Efstathios S Gonos; Christopher Thrasivoulou; M Jill Saffrey; Kerry Cameron; Thomas von Zglinicki
Journal:  Aging Cell       Date:  2012-09-12       Impact factor: 9.304
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  11 in total

Review 1.  Cellular senescence and senolytics: the path to the clinic.

Authors:  Selim Chaib; Tamar Tchkonia; James L Kirkland
Journal:  Nat Med       Date:  2022-08-11       Impact factor: 87.241

Review 2.  Preserving and rejuvenating old organs for transplantation: novel treatments including the potential of senolytics.

Authors:  Tomohisa Matsunaga; Maximilian J Roesel; Andreas Schroeter; Yao Xiao; Hao Zhou; Stefan G Tullius
Journal:  Curr Opin Organ Transplant       Date:  2022-08-09       Impact factor: 2.269

Review 3.  A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease.

Authors:  Huiyi Chen; Feng Chen; Ying Jiang; Lu Zhang; Guizhen Hu; Furong Sun; Miaoping Zhang; Yao Ji; Yanting Chen; Gang Che; Xu Zhou; Yu Zhang
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4.  TNF-α/IFN-γ synergy amplifies senescence-associated inflammation and SARS-CoV-2 receptor expression via hyper-activated JAK/STAT1.

Authors:  Renuka Kandhaya-Pillai; Xiaomeng Yang; Tamar Tchkonia; George M Martin; James L Kirkland; Junko Oshima
Journal:  Aging Cell       Date:  2022-05-30       Impact factor: 11.005

5.  Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans.

Authors:  Yi Zhu; Larissa G P Langhi Prata; Erin O Wissler Gerdes; Jair Machado Espindola Netto; Tamar Pirtskhalava; Nino Giorgadze; Utkarsh Tripathi; Christina L Inman; Kurt O Johnson; Ailing Xue; Allyson K Palmer; Tingjun Chen; Kalli Schaefer; Jamie N Justice; Anoop M Nambiar; Nicolas Musi; Stephen B Kritchevsky; Jun Chen; Sundeep Khosla; Diana Jurk; Marissa J Schafer; Tamar Tchkonia; James L Kirkland
Journal:  EBioMedicine       Date:  2022-03-13       Impact factor: 11.205

6.  Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial.

Authors:  M M Gonzales; V R Garbarino; E Marques Zilli; R C Petersen; J L Kirkland; T Tchkonia; N Musi; S Seshadri; S Craft; M E Orr
Journal:  J Prev Alzheimers Dis       Date:  2022

7.  Senolytic Therapy for Cerebral Ischemia-Reperfusion Injury.

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Journal:  Int J Mol Sci       Date:  2021-11-04       Impact factor: 5.923

Review 8.  Neuroinflammation in Alzheimer's Disease.

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9.  Senescent cells in human adipose tissue: A cross-sectional study.

Authors:  Ana Elena Espinosa De Ycaza; Esben Søndergaard; Maria Morgan-Bathke; Barbara Gisella Carranza Leon; Kelli A Lytle; Paola Ramos; James L Kirkland; Tamar Tchkonia; Michael D Jensen
Journal:  Obesity (Silver Spring)       Date:  2021-06-10       Impact factor: 9.298

Review 10.  Role of senescence in the chronic health consequences of COVID-19.

Authors:  Erin O Wissler Gerdes; Greg Vanichkachorn; Brandon P Verdoorn; Gregory J Hanson; Avni Y Joshi; M Hassan Murad; Stacey A Rizza; Ryan T Hurt; Tamar Tchkonia; James L Kirkland
Journal:  Transl Res       Date:  2021-10-22       Impact factor: 7.012
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