Literature DB >> 27694480

Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants.

Philippe Selhorst1, Lindi Masson1,2, Sherazaan D Ismail1, Natasha Samsunder2, Nigel Garrett2, Leila E Mansoor2, Quarraisha Abdool Karim2,3, Salim S Abdool Karim2,3, Jo-Ann S Passmore1,2,4, Carolyn Williamson1,4.   

Abstract

We evaluated whether genital inflammation affects the selection of the transmitted virus. Among South African women, we found that preinfection genital inflammation facilitates transmission of less infectious human immunodeficiency virus, but highly infectious viruses are able to establish infection regardless of inflammation status. This suggests that viral phenotype can influence transmission risk.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Entities:  

Keywords:  HIV acquisition; cytokine; female genital tract; inflammation; viral infectivity

Mesh：

Substances：

Year:  2016        PMID： 27694480      PMCID： PMC5159604          DOI： 10.1093/cid/ciw663

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  12 in total

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2.  Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

Authors:  Quarraisha Abdool Karim; Salim S Abdool Karim; Janet A Frohlich; Anneke C Grobler; Cheryl Baxter; Leila E Mansoor; Ayesha B M Kharsany; Sengeziwe Sibeko; Koleka P Mlisana; Zaheen Omar; Tanuja N Gengiah; Silvia Maarschalk; Natasha Arulappan; Mukelisiwe Mlotshwa; Lynn Morris; Douglas Taylor
Journal:  Science       Date:  2010-07-19       Impact factor: 47.728

3.  Role of donor genital tract HIV-1 diversity in the transmission bottleneck.

Authors:  Debrah I Boeras; Peter T Hraber; Mackenzie Hurlston; Tammy Evans-Strickfaden; Tanmoy Bhattacharya; Elena E Giorgi; Joseph Mulenga; Etienne Karita; Bette T Korber; Susan Allen; Clyde E Hart; Cynthia A Derdeyn; Eric Hunter
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-07       Impact factor: 11.205

4.  IL-10 synergizes with multiple cytokines in enhancing HIV production in cells of monocytic lineage.

Authors:  D Weissman; G Poli; A S Fauci
Journal:  J Acquir Immune Defic Syndr Hum Retrovirol       Date:  1995-08-15

5.  High-level replication of human immunodeficiency virus in thymocytes requires NF-kappaB activation through interaction with thymic epithelial cells.

Authors:  L Chêne; M T Nugeyre; F Barré-Sinoussi; N Israël
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

6.  Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants.

Authors:  M-R Abrahams; J A Anderson; E E Giorgi; C Seoighe; K Mlisana; L-H Ping; G S Athreya; F K Treurnicht; B F Keele; N Wood; J F Salazar-Gonzalez; T Bhattacharya; H Chu; I Hoffman; S Galvin; C Mapanje; P Kazembe; R Thebus; S Fiscus; W Hide; M S Cohen; S Abdool Karim; B F Haynes; G M Shaw; B H Hahn; B T Korber; R Swanstrom; C Williamson
Journal:  J Virol       Date:  2009-02-04       Impact factor: 5.103

7.  Phenotypic properties of transmitted founder HIV-1.

Authors:  Nicholas F Parrish; Feng Gao; Hui Li; Elena E Giorgi; Hannah J Barbian; Erica H Parrish; Lara Zajic; Shilpa S Iyer; Julie M Decker; Amit Kumar; Bhavna Hora; Anna Berg; Fangping Cai; Jennifer Hopper; Thomas N Denny; Haitao Ding; Christina Ochsenbauer; John C Kappes; Rachel P Galimidi; Anthony P West; Pamela J Bjorkman; Craig B Wilen; Robert W Doms; Meagan O'Brien; Nina Bhardwaj; Persephone Borrow; Barton F Haynes; Mark Muldoon; James P Theiler; Bette Korber; George M Shaw; Beatrice H Hahn
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-29       Impact factor: 11.205

8.  Heterosexual Transmission of Subtype C HIV-1 Selects Consensus-Like Variants without Increased Replicative Capacity or Interferon-α Resistance.

Authors:  Martin J Deymier; Zachary Ende; Angharad E Fenton-May; Dario A Dilernia; William Kilembe; Susan A Allen; Persephone Borrow; Eric Hunter
Journal:  PLoS Pathog       Date:  2015-09-17       Impact factor: 6.823

9.  HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck.

Authors:  Jonathan M Carlson; Malinda Schaefer; Daniela C Monaco; Rebecca Batorsky; Daniel T Claiborne; Jessica Prince; Martin J Deymier; Zachary S Ende; Nichole R Klatt; Charles E DeZiel; Tien-Ho Lin; Jian Peng; Aaron M Seese; Roger Shapiro; John Frater; Thumbi Ndung'u; Jianming Tang; Paul Goepfert; Jill Gilmour; Matt A Price; William Kilembe; David Heckerman; Philip J R Goulder; Todd M Allen; Susan Allen; Eric Hunter
Journal:  Science       Date:  2014-07-10       Impact factor: 47.728

10.  Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1.

Authors:  Richard E Haaland; Paulina A Hawkins; Jesus Salazar-Gonzalez; Amber Johnson; Amanda Tichacek; Etienne Karita; Olivier Manigart; Joseph Mulenga; Brandon F Keele; George M Shaw; Beatrice H Hahn; Susan A Allen; Cynthia A Derdeyn; Eric Hunter
Journal:  PLoS Pathog       Date:  2009-01-23       Impact factor: 6.823
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  23 in total

1.  Replication Capacity of Viruses from Acute Infection Drives HIV-1 Disease Progression.

Authors:  Philippe Selhorst; Carina Combrinck; Nonkululeko Ndabambi; Sherazaan D Ismail; Melissa-Rose Abrahams; Miguel Lacerda; Natasha Samsunder; Nigel Garrett; Quarraisha Abdool Karim; Salim S Abdool Karim; Carolyn Williamson
Journal:  J Virol       Date:  2017-03-29       Impact factor: 5.103

2.  'You'll always stay right': understanding vaginal products and the motivations for use among adolescent and young women in rural KZN.

Authors:  Hilton Humphries; Celia Mehou-Loko; Sithembile Phakathi; Makhosazana Mdladla; Lauren Fynn; Lucia Knight; Quarraisha Abdool Karim
Journal:  Cult Health Sex       Date:  2018-04-16

Review 3.  Hormonal Contraception and HIV-1 Acquisition: Biological Mechanisms.

Authors:  Janet P Hapgood; Charu Kaushic; Zdenek Hel
Journal:  Endocr Rev       Date:  2018-02-01       Impact factor: 19.871

Review 4.  Semen: A modulator of female genital tract inflammation and a vector for HIV-1 transmission.

Authors:  Janine Jewanraj; Sinaye Ngcapu; Lenine J P Liebenberg
Journal:  Am J Reprod Immunol       Date:  2021-06-16       Impact factor: 3.777

Review 5.  Bugs, drugs, and HIV: the role of the vaginal microbiome in HIV risk and antiretroviral efficacy for HIV prevention.

Authors:  Lenine J P Liebenberg; Derseree Archary; Aida Sivro; Douglas S Kwon
Journal:  Genome Med       Date:  2017-08-17       Impact factor: 11.117

6.  Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants.

Authors:  Andrea Introini; Stéphanie Boström; Frideborg Bradley; Anna Gibbs; Axel Glaessgen; Annelie Tjernlund; Kristina Broliden
Journal:  PLoS Pathog       Date:  2017-05-19       Impact factor: 6.823

7.  The HIV-1 transmission bottleneck.

Authors:  Samuel Mundia Kariuki; Philippe Selhorst; Kevin K Ariën; Jeffrey R Dorfman
Journal:  Retrovirology       Date:  2017-03-23       Impact factor: 4.602

Review 8.  Sex Differences in HIV Infection.

Authors:  Eileen P Scully
Journal:  Curr HIV/AIDS Rep       Date:  2018-04       Impact factor: 5.071

9.  Transient association between semen exposure and biomarkers of genital inflammation in South African women at risk of HIV infection.

Authors:  Janine Jewanraj; Sinaye Ngcapu; Farzana Osman; Veron Ramsuran; Maryam Fish; Andile Mtshali; Ravesh Singh; Leila E Mansoor; Salim S Abdool Karim; Quarraisha Abdool Karim; Jo-Ann S Passmore; Lenine J P Liebenberg
Journal:  J Int AIDS Soc       Date:  2021-06       Impact factor: 5.396

10.  Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women.

Authors:  Lyle R McKinnon; Lenine J Liebenberg; Nonhlanhla Yende-Zuma; Derseree Archary; Sinaye Ngcapu; Aida Sivro; Nico Nagelkerke; Jose Gerardo Garcia Lerma; Angela D Kashuba; Lindi Masson; Leila E Mansoor; Quarraisha Abdool Karim; Salim S Abdool Karim; Jo-Ann S Passmore
Journal:  Nat Med       Date:  2018-02-26       Impact factor: 53.440
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