| Literature DB >> 25013080 |
Jonathan M Carlson1, Malinda Schaefer2, Daniela C Monaco2, Rebecca Batorsky3, Daniel T Claiborne2, Jessica Prince2, Martin J Deymier2, Zachary S Ende2, Nichole R Klatt2, Charles E DeZiel4, Tien-Ho Lin4, Jian Peng4, Aaron M Seese3, Roger Shapiro5, John Frater6, Thumbi Ndung'u7, Jianming Tang8, Paul Goepfert8, Jill Gilmour9, Matt A Price10, William Kilembe11, David Heckerman12, Philip J R Goulder13, Todd M Allen14, Susan Allen15, Eric Hunter16.
Abstract
Heterosexual transmission of HIV-1 typically results in one genetic variant establishing systemic infection. We compared, for 137 linked transmission pairs, the amino acid sequences encoded by non-envelope genes of viruses in both partners and demonstrate a selection bias for transmission of residues that are predicted to confer increased in vivo fitness on viruses in the newly infected, immunologically naïve recipient. Although tempered by transmission risk factors, such as donor viral load, genital inflammation, and recipient gender, this selection bias provides an overall transmission advantage for viral quasispecies that are dominated by viruses with high in vivo fitness. Thus, preventative or therapeutic approaches that even marginally reduce viral fitness may lower the overall transmission rates and offer long-term benefits even upon successful transmission.Entities:
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Year: 2014 PMID： 25013080 PMCID： PMC4289910 DOI： 10.1126/science.1254031
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728