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Literature DB >> 27692849

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes.

Anna Raffaello¹, Cristina Mammucari², Gaia Gherardi³, Rosario Rizzuto⁴.

Abstract

In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles that have important implications for whole-cell Ca2+ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+ channels revealed by electron cryomicroscopy (cryo-EM), continuous updates on the structure, regulation, and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca2+ signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca2+ signaling. In this review we summarize recent discoveries on the regulation of interorganellar Ca2+ homeostasis and its role in pathophysiology.

Entities: Chemical

Mesh：

Substances：

Year: 2016 PMID： 27692849 PMCID： PMC5123979 DOI： 10.1016/j.tibs.2016.09.001

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

115 in total

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Authors: Kimberli J Kamer; Vamsi K Mootha
Journal: Nat Rev Mol Cell Biol Date: 2015-08-19 Impact factor: 94.444

2. Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs.

Authors: Rahul Chandrasekhar; Kamil J Alzayady; Larry E Wagner; David I Yule
Journal: J Biol Chem Date: 2016-01-11 Impact factor: 5.157

3. Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria.

Authors: G Csordás; A P Thomas; G Hajnóczky
Journal: EMBO J Date: 1999-01-04 Impact factor: 11.598

4. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.

Authors: Diego De Stefani; Anna Raffaello; Enrico Teardo; Ildikò Szabò; Rosario Rizzuto
Journal: Nature Date: 2011-06-19 Impact factor: 49.962

5. Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor.

Authors: Martin Hohenegger; Josef Suko; Regina Gscheidlinger; Helmut Drobny; Andreas Zidar
Journal: Biochem J Date: 2002-10-15 Impact factor: 3.857

6. Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.

Authors: Dipayan Chaudhuri; Daniel J Artiga; Sunday A Abiria; David E Clapham
Journal: Proc Natl Acad Sci U S A Date: 2016-03-14 Impact factor: 11.205

7. Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.

Authors: D L Clapper; T F Walseth; P J Dargie; H C Lee
Journal: J Biol Chem Date: 1987-07-15 Impact factor: 5.157

Review 8. A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells.

Authors: Antony Galione
Journal: Cell Calcium Date: 2014-10-07 Impact factor: 6.817

9. Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution.

Authors: Zhen Yan; Xiaochen Bai; Chuangye Yan; Jianping Wu; Zhangqiang Li; Tian Xie; Wei Peng; Changcheng Yin; Xueming Li; Sjors H W Scheres; Yigong Shi; Nieng Yan
Journal: Nature Date: 2014-12-15 Impact factor: 49.962

10. Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.

Authors: Rebecca A Capel; Emma L Bolton; Wee K Lin; Daniel Aston; Yanwen Wang; Wei Liu; Xin Wang; Rebecca-Ann B Burton; Duncan Bloor-Young; Kai-Ting Shade; Margarida Ruas; John Parrington; Grant C Churchill; Ming Lei; Antony Galione; Derek A Terrar
Journal: J Biol Chem Date: 2015-10-05 Impact factor: 5.157

152 in total

1. USP16-mediated deubiquitination of calcineurin A controls peripheral T cell maintenance.

Authors: Yu Zhang; Rong-Bei Liu; Qian Cao; Ke-Qi Fan; Ling-Jie Huang; Jian-Shuai Yu; Zheng-Jun Gao; Tao Huang; Jiang-Yan Zhong; Xin-Tao Mao; Fei Wang; Peng Xiao; Yuan Zhao; Xin-Hua Feng; Yi-Yuan Li; Jin Jin
Journal: J Clin Invest Date: 2019-05-28 Impact factor: 14.808

2. Pifithrin-Alpha Reduces Methamphetamine Neurotoxicity in Cultured Dopaminergic Neurons.

Authors: Yun-Hsiang Chen; Eunkyung Bae; Hsi Chen; Seong-Jin Yu; Brandon K Harvey; Nigel H Greig; Yun Wang
Journal: Neurotox Res Date: 2019-05-08 Impact factor: 3.911

3. Lysosomal Calcium in Neurodegeneration.

Authors: Xinghua Feng; Junsheng Yang
Journal: Messenger (Los Angel) Date: 2016-06-01

Review 4. Involvement of organelles and inter-organellar signaling in the pathogenesis of HIV-1 associated neurocognitive disorder and Alzheimer's disease.

Authors: Nabab Khan; Norman J Haughey; Avindra Nath; Jonathan D Geiger
Journal: Brain Res Date: 2019-08-16 Impact factor: 3.252