K Kapur1, G S Joneja2, M Biswas3. 1. Classified Specialist (Obs & Gyn) & Endoscopic Surgeon, Army Hospital (R & R), Delhi Cantt. 2. Senior Advisor (Obs & Gyn), Army Hospital (R & R), Delhi Cantt. 3. Classified Specialist (Obs & Gyn) & Gyn Oncologist, Army Hospital (R & R), Delhi Cantt.
Abstract
BACKGROUND: Termination of early pregnancy has traditionally been done surgically, but agents are now available which can terminate pregnancy if taken orally, vaginally or parenterally. We have used a combination of mifepristone and misoprostol for termination of early pregnancy. MATERIAL AND METHOD: Fifty patients having amenorrhoea of upto 56 days with confirmed intrauterine pregnancy, were selected for medical termination of pregnancy. The patients were given tablet mifepristone (200mg) on day 1 and tablet misoprostol (400mcg) on day 3. On day 14, an ultrasound was done to confirm complete abortion. RESULT: Majority 35 (70%) patients had amenorrhoea between 40 - 50 days. The duration of bleeding was less than 5 days in 12%, between 5 -10 days in 56%, 10 -13 days in 16% and greater than 14 days in 16%. In all patients with bleeding of more than 14 days ultrasonography confirmed intrauterine products & a suction evacuation was done. In this series there were no failures. CONCLUSION: The combination of mifepristone and misoprostol is an effective method for termination of early pregnancy up to 56 days of amenorrhoea.
BACKGROUND: Termination of early pregnancy has traditionally been done surgically, but agents are now available which can terminate pregnancy if taken orally, vaginally or parenterally. We have used a combination of mifepristone and misoprostol for termination of early pregnancy. MATERIAL AND METHOD: Fifty patients having amenorrhoea of upto 56 days with confirmed intrauterine pregnancy, were selected for medical termination of pregnancy. The patients were given tablet mifepristone (200mg) on day 1 and tablet misoprostol (400mcg) on day 3. On day 14, an ultrasound was done to confirm complete abortion. RESULT: Majority 35 (70%) patients had amenorrhoea between 40 - 50 days. The duration of bleeding was less than 5 days in 12%, between 5 -10 days in 56%, 10 -13 days in 16% and greater than 14 days in 16%. In all patients with bleeding of more than 14 days ultrasonography confirmed intrauterine products & a suction evacuation was done. In this series there were no failures. CONCLUSION: The combination of mifepristone and misoprostol is an effective method for termination of early pregnancy up to 56 days of amenorrhoea.
Authors: Helena von Hertzen; Helena Honkanen; Gilda Piaggio; György Bartfai; Radnaabazar Erdenetungalag; Kristina Gemzell-Danielsson; Sarala Gopalan; Mihai Horga; Fridtjof Jerve; Suneeta Mittal; Nguyen Thi Nhu Ngoc; Alexandre Peregoudov; R N V Prasad; Alenka Pretnar-Darovec; Rashmi S Shah; Si Song; Oi Shan Tang; Shang Chun Wu Journal: BJOG Date: 2003-09 Impact factor: 6.531