| Literature DB >> 27686274 |
Abstract
A pathological pathway leading from soluble to insoluble and filamentous tau underlies human tauopathies. This ordered assembly causes disease and is the gain-of-toxic function. It involves the transition from an intrinsically disordered monomer to a highly structured filament. Based on recent findings, one can divide the ordered assembly into propagation of pathology and neurodegeneration. Short tau fibrils constitute the major species of seed-competent tau in the brains of mice transgenic for human P301S tau. The molecular species of aggregated tau that are essential for neurodegeneration remain to be identified.Entities:
Keywords: Alzheimer's disease; Cell-to-cell spreading; Prion-like; Propagation of pathology; Protein strains; Tau; Tauopathy; Toxicity
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Year: 2016 PMID： 27686274 DOI： 10.1016/j.jalz.2016.09.001
Source DB: PubMed Journal: Alzheimers Dement ISSN： 1552-5260 Impact factor: 21.566