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Literature DB >> 28483344

The Exceptional Vulnerability of Humans to Alzheimer's Disease.

Abstract

Like many humans, non-human primates deposit copious misfolded Aβ protein in the brain as they age. Nevertheless, the complete behavioral and pathologic phenotype of Alzheimer's disease, including Aβ plaques, neurofibrillary (tau) tangles, and dementia, has not yet been identified in a non-human species. Recent research suggests that the crucial link between Aβ aggregation and tauopathy is somehow disengaged in aged monkeys. Understanding why Alzheimer's disease fails to develop in species that are biologically proximal to humans could disclose new therapeutic targets in the chain of events leading to neurodegeneration and dementia.

Entities: Chemical Disease Gene Species

Keywords: Aβ; aging; amyloid; dementia; neurodegeneration; non-human primate; prion; proteopathy; seeding; tau

Mesh：

Substances：
Amyloid beta-Peptides

Year: 2017 PMID： 28483344 PMCID： PMC5521004 DOI： 10.1016/j.molmed.2017.04.001

Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951

118 in total

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Journal: Brain Res Date: 2010-01-08 Impact factor: 3.252

Review 8. The Immune System and Neuroinflammation as Potential Sources of Blood-Based Biomarkers for Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease.

Authors: Lorraine F Clark; Thomas Kodadek
Journal: ACS Chem Neurosci Date: 2016-04-14 Impact factor: 4.418

9. A Naturally Occurring Bovine Tauopathy Is Geographically Widespread in the UK.

Authors: Martin Jeffrey; Pedro Piccardo; Diane L Ritchie; James W Ironside; Alison J E Green; Gillian McGovern
Journal: PLoS One Date: 2015-06-19 Impact factor: 3.240

10. An evolutionary roadmap to the microtubule-associated protein MAP Tau.

Authors: Frederik Sündermann; Maria-Pilar Fernandez; Reginald O Morgan
Journal: BMC Genomics Date: 2016-03-31 Impact factor: 3.969

26 in total

1. Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis.

Authors: Jean-Pierre Roussarie; Vicky Yao; Patricia Rodriguez-Rodriguez; Rose Oughtred; Jennifer Rust; Zakary Plautz; Shirin Kasturia; Christian Albornoz; Wei Wang; Eric F Schmidt; Ruth Dannenfelser; Alicja Tadych; Lars Brichta; Alona Barnea-Cramer; Nathaniel Heintz; Patrick R Hof; Myriam Heiman; Kara Dolinski; Marc Flajolet; Olga G Troyanskaya; Paul Greengard
Journal: Neuron Date: 2020-06-29 Impact factor: 17.173

Review 2. Human-Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges.

Authors: Alejandro De Los Angeles; Insoo Hyun; Stephen R Latham; John D Elsworth; D Eugene Redmond
Journal: Stem Cells Dev Date: 2018-12-01 Impact factor: 3.272

3. Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging.

Authors: Danielle Beckman; Sean Ott; Kristine Donis-Cox; William G Janssen; Eliza Bliss-Moreau; Peter H Rudebeck; Mark G Baxter; John H Morrison
Journal: Proc Natl Acad Sci U S A Date: 2019-12-23 Impact factor: 11.205

4. Alzheimer's disease: A clinical perspective and future nonhuman primate research opportunities.

Authors: Rafi U Haque; Allan I Levey
Journal: Proc Natl Acad Sci U S A Date: 2019-12-23 Impact factor: 11.205

5. Aβ Plaques.

Authors: Lary C Walker
Journal: Free Neuropathol Date: 2020-10-30

6. AD-Related N-Terminal Truncated Tau Is Sufficient to Recapitulate In Vivo the Early Perturbations of Human Neuropathology: Implications for Immunotherapy.

Authors: A Borreca; V Latina; V Corsetti; S Middei; S Piccinin; F Della Valle; R Bussani; M Ammassari-Teule; R Nisticò; P Calissano; G Amadoro
Journal: Mol Neurobiol Date: 2018-03-05 Impact factor: 5.590