Literature DB >> 27686184

OTULIN deficiency causes auto-inflammatory syndrome.

Berthe Katrine Fiil1, Mads Gyrd-Hansen1.   

Abstract

Ubiquitin chains assembled via the N-terminal methionine (Met1 or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF-κΒ-dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.

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Year:  2016        PMID： 27686184      PMCID： PMC5099863          DOI： 10.1038/cr.2016.113

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  12 in total

1.  A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7.

Authors:  Kelly Verhelst; Isabelle Carpentier; Marja Kreike; Laura Meloni; Lynn Verstrepen; Tobias Kensche; Ivan Dikic; Rudi Beyaert
Journal:  EMBO J       Date:  2012-08-28       Impact factor: 11.598

2.  Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease.

Authors:  Qing Zhou; Xiaomin Yu; Erkan Demirkaya; Natalie Deuitch; Deborah Stone; Wanxia Li Tsai; Hye Sun Kuehn; Hongying Wang; Dan Yang; Yong Hwan Park; Amanda K Ombrello; Mary Blake; Tina Romeo; Elaine F Remmers; Jae Jin Chae; James C Mullikin; Ferhat Güzel; Joshua D Milner; Manfred Boehm; Sergio D Rosenzweig; Massimo Gadina; Steven B Welch; Seza Özen; Rezan Topaloglu; Mario Abinun; Daniel L Kastner; Ivona Aksentijevich
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-24       Impact factor: 11.205

3.  Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation.

Authors:  Fuminori Tokunaga; Hiroshi Nishimasu; Ryuichiro Ishitani; Eiji Goto; Takuya Noguchi; Kazuhiro Mio; Kiyoko Kamei; Averil Ma; Kazuhiro Iwai; Osamu Nureki
Journal:  EMBO J       Date:  2012-08-28       Impact factor: 11.598

4.  Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN.

Authors:  Tsuyoshi Takiuchi; Tomoko Nakagawa; Hironari Tamiya; Hiroaki Fujita; Yoshiteru Sasaki; Yasushi Saeki; Hiroyuki Takeda; Tatsuya Sawasaki; Alexander Buchberger; Tadashi Kimura; Kazuhiro Iwai
Journal:  Genes Cells       Date:  2014-01-26       Impact factor: 1.891

Review 5.  Linear ubiquitination in immunity.

Authors:  Yutaka Shimizu; Lucia Taraborrelli; Henning Walczak
Journal:  Immunol Rev       Date:  2015-07       Impact factor: 12.988

6.  LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes.

Authors:  Peter Draber; Sebastian Kupka; Matthias Reichert; Helena Draberova; Elodie Lafont; Diego de Miguel; Lisanne Spilgies; Silvia Surinova; Lucia Taraborrelli; Torsten Hartwig; Eva Rieser; Luigi Martino; Katrin Rittinger; Henning Walczak
Journal:  Cell Rep       Date:  2015-12-06       Impact factor: 9.423

7.  Molecular basis and regulation of OTULIN-LUBAC interaction.

Authors:  Paul R Elliott; Sofie V Nielsen; Paola Marco-Casanova; Berthe Katrine Fiil; Kirstin Keusekotten; Niels Mailand; Stefan M V Freund; Mads Gyrd-Hansen; David Komander
Journal:  Mol Cell       Date:  2014-04-10       Impact factor: 19.328

8.  CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling.

Authors:  Matous Hrdinka; Berthe Katrine Fiil; Mattia Zucca; Derek Leske; Katrin Bagola; Monica Yabal; Paul R Elliott; Rune Busk Damgaard; David Komander; Philipp J Jost; Mads Gyrd-Hansen
Journal:  Cell Rep       Date:  2016-03-17       Impact factor: 9.423

9.  The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.

Authors:  Elena Rivkin; Stephanie M Almeida; Derek F Ceccarelli; Yu-Chi Juang; Teresa A MacLean; Tharan Srikumar; Hao Huang; Wade H Dunham; Ryutaro Fukumura; Gang Xie; Yoichi Gondo; Brian Raught; Anne-Claude Gingras; Frank Sicheri; Sabine P Cordes
Journal:  Nature       Date:  2013-05-24       Impact factor: 49.962

10.  The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.

Authors:  Rune Busk Damgaard; Jennifer A Walker; Paola Marco-Casanova; Neil V Morgan; Hannah L Titheradge; Paul R Elliott; Duncan McHale; Eamonn R Maher; Andrew N J McKenzie; David Komander
Journal:  Cell       Date:  2016-08-11       Impact factor: 41.582
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  5 in total

1.  The Superimposed Deubiquitination Effect of OTULIN and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Nsp11 Promotes Multiplication of PRRSV.

Authors:  Yanxin Su; Peidian Shi; Lilin Zhang; Dong Lu; Chengxue Zhao; Ruiqiao Li; Lei Zhang; Jinhai Huang
Journal:  J Virol       Date:  2018-04-13       Impact factor: 5.103

2.  Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function.

Authors:  Eric Shifrut; Julia Carnevale; Victoria Tobin; Theodore L Roth; Jonathan M Woo; Christina T Bui; P Jonathan Li; Morgan E Diolaiti; Alan Ashworth; Alexander Marson
Journal:  Cell       Date:  2018-11-15       Impact factor: 41.582

Review 3.  The Impact of Acute or Chronic Alcohol Intake on the NF-κB Signaling Pathway in Alcohol-Related Liver Disease.

Authors:  Aleksander J Nowak; Borna Relja
Journal:  Int J Mol Sci       Date:  2020-12-10       Impact factor: 5.923

Review 4.  Deubiquitinases: Modulators of Different Types of Regulated Cell Death.

Authors:  Choong-Sil Lee; Seungyeon Kim; Gyuho Hwang; Jaewhan Song
Journal:  Int J Mol Sci       Date:  2021-04-21       Impact factor: 5.923

Review 5.  The Role of Deubiquitinating Enzymes in Acute Lung Injury and Acute Respiratory Distress Syndrome.

Authors:  Tiao Li; Chunbin Zou
Journal:  Int J Mol Sci       Date:  2020-07-08       Impact factor: 5.923
  5 in total

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