Hong-Yan Zhou1, Shuang Wang1, Hong Zhang1, Ling Wang1, Wen-Song Zhang2. 1. Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China. 2. Department of Ophthalmology, the Second Hospital of Jilin University, Changchun 130033, Jilin Province, China.
Abstract
AIM: To investigate a practical technique used to inhibit corneal angiogenesis with a (90)Sr-(90)Y ophthalmic applicator. METHODS: A (90)Sr-(90)Y ophthalmic applicator was detected with a radioactive nuclide application treatment healthy protection standard. The applicator used was produced through medical dosimetry research; it had a concave applicator add measured the applicator temperature, serviceable humidity range, applicator appearance status, applicator radiation homogeneity, radioautography, and radiological safety of the original applicator surface. A vessel model was established using newborn rats, with sutures around the corneal limbus. Corneal neovascularization (CNV) were observed with a slit lamp. The new vessel length and response area were measured. RESULTS: Low-dose radiation can inhibit CNV after corneal sutures. The absorbed dose of the applicator (0.046 Gy/s) was safe for the treatment of it. The lengths of new vessels and the areas of new vessels were lower than the new born vessel rat group (P<0.01). CONCLUSION: The optimal radiation dose emitting from the applicator can be safe and potentially used in humans.
AIM: To investigate a practical technique used to inhibit corneal angiogenesis with a (90)Sr-(90)Y ophthalmic applicator. METHODS: A (90)Sr-(90)Y ophthalmic applicator was detected with a radioactive nuclide application treatment healthy protection standard. The applicator used was produced through medical dosimetry research; it had a concave applicator add measured the applicator temperature, serviceable humidity range, applicator appearance status, applicator radiation homogeneity, radioautography, and radiological safety of the original applicator surface. A vessel model was established using newborn rats, with sutures around the corneal limbus. Corneal neovascularization (CNV) were observed with a slit lamp. The new vessel length and response area were measured. RESULTS: Low-dose radiation can inhibit CNV after corneal sutures. The absorbed dose of the applicator (0.046 Gy/s) was safe for the treatment of it. The lengths of new vessels and the areas of new vessels were lower than the new born vessel rat group (P<0.01). CONCLUSION: The optimal radiation dose emitting from the applicator can be safe and potentially used in humans.
Authors: Konstantin Gaengel; Colin Niaudet; Kazuhiro Hagikura; Bàrbara Laviña; Bàrbara Laviña Siemsen; Lars Muhl; Jennifer J Hofmann; Lwaki Ebarasi; Staffan Nyström; Simin Rymo; Long Long Chen; Mei-Fong Pang; Yi Jin; Elisabeth Raschperger; Pernilla Roswall; Dörte Schulte; Rui Benedito; Jimmy Larsson; Mats Hellström; Jonas Fuxe; Per Uhlén; Ralf Adams; Lars Jakobsson; Arindam Majumdar; Dietmar Vestweber; Anne Uv; Christer Betsholtz Journal: Dev Cell Date: 2012-09-11 Impact factor: 12.270
Authors: Thomas M Schiele; Jan Herbst; Barbara Pöllinger; Johannes Rieber; Andreas König; Hae-Young Sohn; Florian Krötz; Marcus Leibig; Claus Belka; Volker Klauss Journal: Acute Card Care Date: 2011-01-18
Authors: Francesca Caccuri; Cinzia Giagulli; Antonella Bugatti; Anna Benetti; Giulio Alessandri; Domenico Ribatti; Stefania Marsico; Paola Apostoli; Mark A Slevin; Marco Rusnati; Carlos A Guzman; Simona Fiorentini; Arnaldo Caruso Journal: Proc Natl Acad Sci U S A Date: 2012-08-17 Impact factor: 11.205