Jinjin Zhang1, Hattie L Ring1,2, Katie R Hurley2, Qi Shao3, Cathy S Carlson4, Djaudat Idiyatullin1, Navid Manuchehrabadi5, P Jack Hoopes6, Christy L Haynes2, John C Bischof3,5, Michael Garwood1. 1. Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA. 2. Department of Chemistry, University of Minnesota, Minneapolis, Minnesota, USA. 3. Department of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA. 4. Veterinary Population Medicine, University of Minnesota, Minneapolis, Minnesota, USA. 5. Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA. 6. Department of Surgery and Radiation Oncology, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire, USA.
Abstract
PURPOSE: To use contrast based on longitudinal relaxation times (T1 ) or rates (R1 ) to quantify the biodistribution of iron oxide nanoparticles (IONPs), which are of interest for hyperthermia therapy, cell targeting, and drug delivery, within primary clearance organs. METHODS: Mesoporous silica-coated IONPs (msIONPs) were intravenously injected into 15 naïve mice. Imaging and mapping of the longitudinal relaxation rate constant at 24 h or 1 week postinjection were performed with an echoless pulse sequence (SWIFT). Alternating magnetic field heating measurements were also performed on ex vivo tissues. RESULTS: Signal enhancement from positive T1 contrast caused by IONPs was observed and quantified in vivo in liver, spleen, and kidney at concentrations up to 3.2 mg Fe/(g tissue wt.) (61 mM Fe). In most cases, each organ had a linear correlation between the R1 and the tissue iron concentration despite variations in intra-organ distribution, degradation, and IONP surface charge. Linear correlation between R1 and volumetric SAR in hyperthermia therapy was observed. CONCLUSION: The linear dependence between R1 and tissue iron concentration in major organs allows quantitative monitoring of IONP biodistribution in a dosage range relevant to magnetic hyperthermia applications, which falls into the concentration gap between CT and conventional MRI techniques. Magn Reson Med 78:702-712, 2017.
PURPOSE: To use contrast based on longitudinal relaxation times (T1 ) or rates (R1 ) to quantify the biodistribution of iron oxidenanoparticles (IONPs), which are of interest for hyperthermia therapy, cell targeting, and drug delivery, within primary clearance organs. METHODS: Mesoporous silica-coated IONPs (msIONPs) were intravenously injected into 15 naïve mice. Imaging and mapping of the longitudinal relaxation rate constant at 24 h or 1 week postinjection were performed with an echoless pulse sequence (SWIFT). Alternating magnetic field heating measurements were also performed on ex vivo tissues. RESULTS: Signal enhancement from positive T1 contrast caused by IONPs was observed and quantified in vivo in liver, spleen, and kidney at concentrations up to 3.2 mg Fe/(g tissue wt.) (61 mM Fe). In most cases, each organ had a linear correlation between the R1 and the tissue iron concentration despite variations in intra-organ distribution, degradation, and IONP surface charge. Linear correlation between R1 and volumetric SAR in hyperthermia therapy was observed. CONCLUSION: The linear dependence between R1 and tissue iron concentration in major organs allows quantitative monitoring of IONP biodistribution in a dosage range relevant to magnetic hyperthermia applications, which falls into the concentration gap between CT and conventional MRI techniques. Magn Reson Med 78:702-712, 2017.
Authors: Michael L Etheridge; Katie R Hurley; Jinjin Zhang; Seongho Jeon; Hattie L Ring; Christopher Hogan; Christy L Haynes; Michael Garwood; John C Bischof Journal: Technology (Singap World Sci) Date: 2014-09
Authors: Katie R Hurley; Hattie L Ring; Michael Etheridge; Jinjin Zhang; Zhe Gao; Qi Shao; Nathan D Klein; Victoria M Szlag; Connie Chung; Theresa M Reineke; Michael Garwood; John C Bischof; Christy L Haynes Journal: Mol Pharm Date: 2016-04-04 Impact factor: 4.939
Authors: P R Ros; P C Freeny; S E Harms; S E Seltzer; P L Davis; T W Chan; A E Stillman; L R Muroff; V M Runge; M A Nissenbaum Journal: Radiology Date: 1995-08 Impact factor: 11.105
Authors: Rebecca Kuhlpeter; Hannes Dahnke; Lars Matuszewski; Thorsten Persigehl; Angelika von Wallbrunn; Thomas Allkemper; Walter L Heindel; Tobias Schaeffter; Christoph Bremer Journal: Radiology Date: 2007-09-11 Impact factor: 11.105
Authors: Hattie L Ring; Zhe Gao; Anirudh Sharma; Zonghu Han; Charles Lee; Kelvin G M Brockbank; Elizabeth D Greene; Kristi L Helke; Zhen Chen; Lia H Campbell; Bradley Weegman; Monica Davis; Michael Taylor; Sebastian Giwa; Gregory M Fahy; Brian Wowk; Roberto Pagotan; John C Bischof; Michael Garwood Journal: Magn Reson Med Date: 2019-12-09 Impact factor: 4.668
Authors: Hattie L Ring; Jinjin Zhang; Nathan D Klein; Lynn E Eberly; Christy L Haynes; Michael Garwood Journal: Magn Reson Med Date: 2017-06-26 Impact factor: 4.668
Authors: Navid Manuchehrabadi; Zhe Gao; Jinjin Zhang; Hattie L Ring; Qi Shao; Feng Liu; Michael McDermott; Alex Fok; Yoed Rabin; Kelvin G M Brockbank; Michael Garwood; Christy L Haynes; John C Bischof Journal: Sci Transl Med Date: 2017-03-01 Impact factor: 17.956