| Literature DB >> 27665024 |
Abstract
Recent comprehensive genetic studies revealed numerous genetic aberrations underlying a group of high-risk leukemias that share a specific activated kinase gene expression pattern. These ALLs were first recognized by the expression profile similar to that of Philadelphia chromosome-positive ALL and currently can be sub-classified by the main aberrantly activated kinase in the leukemic cells. We herein review the biological mechanisms and diagnostic and clinical challenges presented by these leukemias.Entities:
Keywords: BCR-ABL-like ALL; JAK inhibitors; Kinase-driven ALL; Ph-like ALL; Tyrosine kinase inhibitors
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Year: 2016 PMID： 27665024 DOI： 10.1016/j.blre.2016.09.001
Source DB: PubMed Journal: Blood Rev ISSN： 0268-960X Impact factor: 8.250