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Literature DB >> 27658485

Sex as a Biological Variable: Who, What, When, Why, and How.

Tracy L Bale^1,2,3, C Neill Epperson^2,3,4.

Abstract

The inclusion of sex as a biological variable in research is absolutely essential for improving our understanding of disease mechanisms contributing to risk and resilience. Studies focusing on examining sex differences have demonstrated across many levels of analyses and stages of brain development and maturation that males and females can differ significantly. This review will discuss examples of animal models and clinical studies to provide guidance and reference for the inclusion of sex as an important biological variable relevant to a Neuropsychopharmacology audience.

Mesh：

Substances：
Gonadal Steroid Hormones

Year: 2016 PMID： 27658485 PMCID： PMC5399243 DOI： 10.1038/npp.2016.215

Source DB: PubMed Journal: Neuropsychopharmacology ISSN： 0893-133X Impact factor: 7.853

120 in total

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Authors: Dawn Kingston; Suzanne Tough; Heather Whitfield
Journal: Child Psychiatry Hum Dev Date: 2012-10

Review 2. Importance of studying the contributions of early adverse experience to neurobiological findings in depression.

Authors: Christine Heim; Paul M Plotsky; Charles B Nemeroff
Journal: Neuropsychopharmacology Date: 2004-04 Impact factor: 7.853

Review 3. Estrogen: consequences and implications of human mutations in synthesis and action.

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Review 4. Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease.

Authors: J M Goldstein; R J Handa; S A Tobet
Journal: Front Neuroendocrinol Date: 2013-12-16 Impact factor: 8.606

Review 5. Neurobiological and psychiatric consequences of child abuse and neglect.

Authors: Christine Heim; Margaret Shugart; W Edward Craighead; Charles B Nemeroff
Journal: Dev Psychobiol Date: 2010-11 Impact factor: 3.038

6. Organizational effects of fetal testosterone on human corpus callosum size and asymmetry.

Authors: Lindsay R Chura; Michael V Lombardo; Emma Ashwin; Bonnie Auyeung; Bhismadev Chakrabarti; Edward T Bullmore; Simon Baron-Cohen
Journal: Psychoneuroendocrinology Date: 2010-01 Impact factor: 4.905

Review 7. Sexually dimorphic responses to early adversity: implications for affective problems and autism spectrum disorder.

Authors: Elysia Poggi Davis; Donald Pfaff
Journal: Psychoneuroendocrinology Date: 2014-06-26 Impact factor: 4.905

Review 8. A role for the androgen metabolite, 5alpha-androstane-3beta,17beta-diol, in modulating oestrogen receptor beta-mediated regulation of hormonal stress reactivity.

Authors: R J Handa; M J Weiser; D G Zuloaga
Journal: J Neuroendocrinol Date: 2009-03 Impact factor: 3.627

9. Sex Differences Research, Precision Medicine, and the Future of Women's Health.

Authors: Virginia M Miller; Walter A Rocca; Stephanie S Faubion
Journal: J Womens Health (Larchmt) Date: 2015-09-01 Impact factor: 2.681

10. Estrogen impairs glucocorticoid dependent negative feedback on the hypothalamic-pituitary-adrenal axis via estrogen receptor alpha within the hypothalamus.

Authors: M J Weiser; R J Handa
Journal: Neuroscience Date: 2009-01-07 Impact factor: 3.590

51 in total

Review 1. Synthesizing Views to Understand Sex Differences in Response to Early Life Adversity.

Authors: Kevin G Bath
Journal: Trends Neurosci Date: 2020-03-16 Impact factor: 13.837

2. Thalamic Cortical Error-Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use.

Authors: Jaime S Ide; Simon Zhornitsky; Herta H Chao; Sheng Zhang; Sien Hu; Wuyi Wang; John H Krystal; Chiang-Shan R Li
Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2018-05-03

Review 3. Sex bias and omission in neuroscience research is influenced by research model and journal, but not reported NIH funding.

Authors: Gabriella M Mamlouk; David M Dorris; Lily R Barrett; John Meitzen
Journal: Front Neuroendocrinol Date: 2020-02-15 Impact factor: 8.606

4. Evidence for distinct biodevelopmental influences on male sexual orientation.

Authors: Ashlyn Swift-Gallant; Lindsay A Coome; Madison Aitken; D Ashley Monks; Doug P VanderLaan
Journal: Proc Natl Acad Sci U S A Date: 2019-06-10 Impact factor: 11.205

5. NPP: Our Designs for the Future.

Authors: William A Carlezon; Anissa Abi-Dargham
Journal: Neuropsychopharmacology Date: 2017-06 Impact factor: 7.853

6. Filling the Regulatory Gap: Potential Role of Institutional Review Boards in Promoting Consideration of Sex as a Biological Variable.

Authors: Korrina A Duffy; Tracy A Ziolek; C Neill Epperson
Journal: J Womens Health (Larchmt) Date: 2020-04-08 Impact factor: 2.681

Review 7. Temperature regulation in women: Effects of the menstrual cycle.

Authors: Fiona C Baker; Felicia Siboza; Andrea Fuller
Journal: Temperature (Austin) Date: 2020-03-22

Review 8. Genomic and epigenomic mechanisms of glucocorticoids in the brain.

Authors: Jason D Gray; Joshua F Kogan; Jordan Marrocco; Bruce S McEwen
Journal: Nat Rev Endocrinol Date: 2017-09-01 Impact factor: 43.330

9. Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment.

Authors: Susan E Maloney; Catherine E Creeley; Richard E Hartman; Carla M Yuede; Charles F Zorumski; Vesna Jevtovic-Todorovic; Krikor Dikranian; Kevin K Noguchi; Nuri B Farber; David F Wozniak
Journal: Neurobiol Learn Mem Date: 2018-03-14 Impact factor: 2.877

10. Men and women differ in the neural basis of handwriting.

Authors: Yang Yang; Fred Tam; Simon J Graham; Guochen Sun; Junjun Li; Chanyuan Gu; Ran Tao; Nizhuan Wang; Hong-Yan Bi; Zhentao Zuo
Journal: Hum Brain Mapp Date: 2020-02-24 Impact factor: 5.038