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Literature DB >> 27658022

Eukaryotic transcription initiation machinery visualized at molecular level.

Abstract

The structures of RNA Polymerase (Pol) II pre-initiation complexes (PIC) have recently been determined at near-atomic resolution, elucidating unprecedented mechanistic details of promoter opening during transcription initiation. The key structural features of promoter opening are summarized here. Structural knowledge of Pol I and III PIC is also briefly discussed.

Entities: Disease

Keywords: RNA polymerase; general transcription factor; pre-initiation complex; promoter opening; transcription initiation

Mesh：

Substances：

Year: 2016 PMID： 27658022 PMCID： PMC5066506 DOI： 10.1080/21541264.2016.1237150

Source DB: PubMed Journal: Transcription ISSN： 2154-1272

40 in total

Review 1. Recruitment of RNA polymerase III to its target promoters.

Authors: Laura Schramm; Nouria Hernandez
Journal: Genes Dev Date: 2002-10-15 Impact factor: 11.361

2. RNA polymerase II-associated proteins are required for a DNA conformation change in the transcription initiation complex.

Authors: S Buratowski; M Sopta; J Greenblatt; P A Sharp
Journal: Proc Natl Acad Sci U S A Date: 1991-09-01 Impact factor: 11.205

3. Mapping the protein interaction network for TFIIB-related factor Brf1 in the RNA polymerase III preinitiation complex.

Authors: Seok-Kooi Khoo; Chih-Chien Wu; Yu-Chun Lin; Jin-Cheng Lee; Hung-Ta Chen
Journal: Mol Cell Biol Date: 2013-11-25 Impact factor: 4.272

Eukaryotic transcription initiation machinery visualized at molecular level.

Review 1. Recruitment of RNA polymerase III to its target promoters.

2. RNA polymerase II-associated proteins are required for a DNA conformation change in the transcription initiation complex.

3. Mapping the protein interaction network for TFIIB-related factor Brf1 in the RNA polymerase III preinitiation complex.

4. Architecture of the RNA polymerase II-Mediator core initiation complex.

5. Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms.

6. TAF1B is a TFIIB-like component of the basal transcription machinery for RNA polymerase I.

7. RNA polymerase I structure and transcription regulation.

8. Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism.

9. Architecture of the RNA polymerase II preinitiation complex and mechanism of ATP-dependent promoter opening.

10. Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.

Review 1. Target acquired: transcriptional regulators as drug targets for protozoan parasites.

2. Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.

3. Spt4 Promotes Pol I Processivity and Transcription Elongation.