Yuqiu Zhang1, Wen Wen1, Xinghuai Sun1. 1. Department of Ophthalmology & Visual Science, Eye and Ear Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China 2State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China 3Key Laboratory of Myopia, Ministry of Health, Fudan University, Shanghai, China 4Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China.
Abstract
PURPOSE: To compare the diagnostic powers of parameters of the RTVue and Cirrus-HD optical coherence tomography (OCT) systems in detecting glaucoma in highly myopic eyes. METHODS: For this study, 28 glaucoma patients with high myopia (HM-G) and 28 high-myopia controls (HM-C) were enrolled. The circumpapillary retinal nerve fiber layer (cp-RNFL) and ganglion cell complex (GCC) parameters in the RTVue-OCT, and the ganglion cell-inner plexiform layer (GCIPL) and cp-RNFL parameters in the Cirrus HD-OCT, were obtained for each subject. The receiver operating characteristics curve (ROC) was used to assess the diagnostic ability of each parameter, and the areas under the curves (AUROCs) of those parameters were compared. RESULTS: In both OCTs, the macular parameters showed significantly higher diagnostic power than the cp-RNFL thickness. The minimum GCIPL (0.977), inferotemporal GCIPL (0.947), and vertical cup/disc (C/D) ratio (0.968) showed the best performances among all of the Cirrus HD-OCT parameters. The focal loss volume (FLV) (0.964), global loss volume (GLV) (0.899), and vertical C/D ratio (0.899) showed the best performances among all of the RTVue-OCT parameters. Among the parameters with high diagnostic ability in each protocol of the two OCTs, the superior sector of the cp-RNFL had significantly lower abilities than the FLV and the minimum of the GCIPL (P < 0.05) in detecting glaucoma in high myopia. CONCLUSIONS: The macular measurements had significantly better glaucoma detection abilities than the cpRNFL thickness in the high-myopia subjects in both RTVue-OCT and Cirrus HD-OCT, with no significant differences in the diagnostic ability between the two macular parameters.
PURPOSE: To compare the diagnostic powers of parameters of the RTVue and Cirrus-HD optical coherence tomography (OCT) systems in detecting glaucoma in highly myopic eyes. METHODS: For this study, 28 glaucoma patients with high myopia (HM-G) and 28 high-myopia controls (HM-C) were enrolled. The circumpapillary retinal nerve fiber layer (cp-RNFL) and ganglion cell complex (GCC) parameters in the RTVue-OCT, and the ganglion cell-inner plexiform layer (GCIPL) and cp-RNFL parameters in the Cirrus HD-OCT, were obtained for each subject. The receiver operating characteristics curve (ROC) was used to assess the diagnostic ability of each parameter, and the areas under the curves (AUROCs) of those parameters were compared. RESULTS: In both OCTs, the macular parameters showed significantly higher diagnostic power than the cp-RNFL thickness. The minimum GCIPL (0.977), inferotemporal GCIPL (0.947), and vertical cup/disc (C/D) ratio (0.968) showed the best performances among all of the Cirrus HD-OCT parameters. The focal loss volume (FLV) (0.964), global loss volume (GLV) (0.899), and vertical C/D ratio (0.899) showed the best performances among all of the RTVue-OCT parameters. Among the parameters with high diagnostic ability in each protocol of the two OCTs, the superior sector of the cp-RNFL had significantly lower abilities than the FLV and the minimum of the GCIPL (P < 0.05) in detecting glaucoma in high myopia. CONCLUSIONS: The macular measurements had significantly better glaucoma detection abilities than the cpRNFL thickness in the high-myopia subjects in both RTVue-OCT and Cirrus HD-OCT, with no significant differences in the diagnostic ability between the two macular parameters.