Literature DB >> 2765397

Muscle fibre necrosis induced by intramuscular injection of drugs.

D Manor1, M Sadeh.   

Abstract

A number of amphiphilic and lipid-soluble drugs of heterogeneous pharmacological properties, when injected into rat anterior tibial muscles, induced acute muscle fibre necrosis. The myotoxic agents were: penicillin, cloxacillin, phenobarbital, haloperidol, diazepam, hydantoin, metoclopramide, pentazocine and chlorpromazine. The regenerative process, studied using the latter three medications, showed rapid regeneration, complete within 3 weeks. Injection of the water-soluble drugs aminophylline, tranexamic acid and vitamins B6 and B12 produced no tissue damage. The pathogenesis of muscle fibre necrosis is suggested to involve direct damage to cell membranes by lipid soluble drugs.

Entities:  

Mesh：

Year:  1989        PMID： 2765397      PMCID： PMC2040563     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  17 in total

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Journal:  Neurol Clin       Date:  1988-08       Impact factor: 3.806

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Journal:  Anat Rec       Date:  1978-07

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Journal:  Toxicol Appl Pharmacol       Date:  1980-02       Impact factor: 4.219

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Authors:  H R Seibel; M F Dolwick; F M Bush; S S Craig
Journal:  Acta Anat (Basel)       Date:  1978

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Journal:  JAMA       Date:  1975-11-10       Impact factor: 56.272

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Authors:  E C Hall-Craggs
Journal:  Exp Neurol       Date:  1974-05       Impact factor: 5.330
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  6 in total

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Journal:  J Toxicol Pathol       Date:  2013       Impact factor: 1.628

5.  Peri-articular tranexamic acid injection in total knee arthroplasty: a randomized controlled trial.

Authors:  P Pinsornsak; S Rojanavijitkul; S Chumchuen
Journal:  BMC Musculoskelet Disord       Date:  2016-07-26       Impact factor: 2.362

6.  Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration.

Authors:  Shen'ao Zhou; Wei Zhang; Gaihong Cai; Yingzhe Ding; Caixia Wei; Sheng Li; Yu Yang; Jie Qin; Dan Liu; Hao Zhang; Xiexiang Shao; Jianhua Wang; Hongye Wang; Wenjun Yang; Huating Wang; She Chen; Ping Hu; Liming Sun
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  6 in total

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