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Literature DB >> 27652328

InsP3R, the calcium whisperer: Maintaining mitochondrial function in cancer.

Alenka Lovy¹, J Kevin Foskett², César Cárdenas³.

Abstract

Mitochondrial metabolism is essential to fulfill the large demand for macromolecule biosynthesis in cancer. We recently identified low-level InsP3R-mediated Ca(2+) transfer to mitochondria as an unexpected requirement for mitochondrial function. Here we reveal that its absence specifically targets cancer cells and causes necrosis at daughter cell separation during ongoing proliferation.

Entities: Chemical Disease

Keywords: AMPK; MCU; OXPHOS; autophagy; cell cycle; necrosis

Year: 2016 PMID： 27652328 PMCID： PMC4972124 DOI： 10.1080/23723556.2016.1185563

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

Review 1. Inositol trisphosphate receptor Ca2+ release channels.

Authors: J Kevin Foskett; Carl White; King-Ho Cheung; Don-On Daniel Mak
Journal: Physiol Rev Date: 2007-04 Impact factor: 37.312

Review 2. Brick by brick: metabolism and tumor cell growth.

Authors: Ralph J Deberardinis; Nabil Sayed; Dara Ditsworth; Craig B Thompson
Journal: Curr Opin Genet Dev Date: 2008-04-02 Impact factor: 5.578

Review 3. Role of mitochondrial Ca2+ in the regulation of cellular energetics.

Authors: Brian Glancy; Robert S Balaban
Journal: Biochemistry Date: 2012-03-29 Impact factor: 3.162

4. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

Authors: César Cárdenas; Russell A Miller; Ian Smith; Thi Bui; Jordi Molgó; Marioly Müller; Horia Vais; King-Ho Cheung; Jun Yang; Ian Parker; Craig B Thompson; Morris J Birnbaum; Kenneth R Hallows; J Kevin Foskett
Journal: Cell Date: 2010-07-23 Impact factor: 41.582

Review 5. Otto Warburg's contributions to current concepts of cancer metabolism.

Authors: Willem H Koppenol; Patricia L Bounds; Chi V Dang
Journal: Nat Rev Cancer Date: 2011-04-14 Impact factor: 60.716

6. Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria.

Authors: César Cárdenas; Marioly Müller; Andrew McNeal; Alenka Lovy; Fabian Jaňa; Galdo Bustos; Felix Urra; Natalia Smith; Jordi Molgó; J Alan Diehl; Todd W Ridky; J Kevin Foskett
Journal: Cell Rep Date: 2016-03-03 Impact factor: 9.423

7. MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

Authors: Karthik Mallilankaraman; Patrick Doonan; César Cárdenas; Harish C Chandramoorthy; Marioly Müller; Russell Miller; Nicholas E Hoffman; Rajesh Kumar Gandhirajan; Jordi Molgó; Morris J Birnbaum; Brad S Rothberg; Don-On Daniel Mak; J Kevin Foskett; Muniswamy Madesh
Journal: Cell Date: 2012-10-26 Impact factor: 41.582

Review 8. Structure and function of the mitochondrial calcium uniporter complex.

Authors: Diego De Stefani; Maria Patron; Rosario Rizzuto
Journal: Biochim Biophys Acta Date: 2015-04-18

9. Mitochondria as biosynthetic factories for cancer proliferation.

Authors: Christopher S Ahn; Christian M Metallo
Journal: Cancer Metab Date: 2015-01-25

10. MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.

Authors: Karthik Mallilankaraman; César Cárdenas; Patrick J Doonan; Harish C Chandramoorthy; Krishna M Irrinki; Tünde Golenár; György Csordás; Priyanka Madireddi; Jun Yang; Marioly Müller; Russell Miller; Jill E Kolesar; Jordi Molgó; Brett Kaufman; György Hajnóczky; J Kevin Foskett; Muniswamy Madesh
Journal: Nat Cell Biol Date: 2012-11-25 Impact factor: 28.824

10 in total

8 in total

Review 1. The role of the mitochondrial calcium uniporter (MCU) complex in cancer.

Authors: Adina Vultur; Christine S Gibhardt; Hedwig Stanisz; Ivan Bogeski
Journal: Pflugers Arch Date: 2018-06-21 Impact factor: 3.657

Review 2. Targeting Bcl-2-IP₃ receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones.

Authors: Clark W Distelhorst
Journal: Biochim Biophys Acta Mol Cell Res Date: 2018-07-25 Impact factor: 4.739

Review 3. Endoplasmic Reticulum-Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer: A Novel Potential Target.

Authors: Galdo Bustos; Pablo Cruz; Alenka Lovy; César Cárdenas
Journal: Front Oncol Date: 2017-09-08 Impact factor: 6.244

4. Editorial: Inter-Organelle Calcium Communication in Cancer.

Authors: Cesar Cardenas; Paolo Pinton; Geert Bultynck
Journal: Front Oncol Date: 2018-02-06 Impact factor: 6.244

Review 5. The Mitochondrial Complex(I)ty of Cancer.

Authors: Félix A Urra; Felipe Muñoz; Alenka Lovy; César Cárdenas
Journal: Front Oncol Date: 2017-06-08 Impact factor: 6.244

6. Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis.

Authors: Kristopher Burkewitz; Gaomin Feng; Sneha Dutta; Charlotte A Kelley; Michael Steinbaugh; Erin J Cram; William B Mair
Journal: Cell Rep Date: 2020-09-08 Impact factor: 9.423

Review 7. Modulation of Ca²⁺ Signaling by Anti-apoptotic B-Cell Lymphoma 2 Proteins at the Endoplasmic Reticulum-Mitochondrial Interface.

Authors: Tim Vervliet; Eva Clerix; Bruno Seitaj; Hristina Ivanova; Giovanni Monaco; Geert Bultynck
Journal: Front Oncol Date: 2017-05-03 Impact factor: 6.244

8. FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.

Authors: Félix A Urra; Felipe Muñoz; Miguel Córdova-Delgado; María Paz Ramírez; Bárbara Peña-Ahumada; Melany Rios; Pablo Cruz; Ulises Ahumada-Castro; Galdo Bustos; Eduardo Silva-Pavez; Rodrigo Pulgar; Danna Morales; Diego Varela; Juan Pablo Millas-Vargas; Evelyn Retamal; Oney Ramírez-Rodríguez; Hernán Pessoa-Mahana; Mario Pavani; Jorge Ferreira; César Cárdenas; Ramiro Araya-Maturana
Journal: Sci Rep Date: 2018-09-04 Impact factor: 4.379