Literature DB >> 27652327

Continuous chromosomal instability in human pluripotent stem cells - the role of DNA replication.

Noa Lamm1, Batsheva Kerem1.   

Abstract

Human pluripotent stem cells (hPSCs) frequently acquire chromosomal aberrations, including aneuploidy, during culture. Recently, we identified a replication stress-based mechanism leading to ongoing chromosomal instability in aneuploid hPSCs that may also operate during the initiation of instability in diploid cells.

Entities:  

Year:  2016        PMID： 27652327      PMCID： PMC4972117          DOI： 10.1080/23723556.2016.1183743

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects.

Authors:  Noa Lamm; Uri Ben-David; Tamar Golan-Lev; Zuzana Storchová; Nissim Benvenisty; Batsheva Kerem
Journal:  Cell Stem Cell       Date:  2015-12-05       Impact factor: 24.633

2.  Large-scale analysis reveals acquisition of lineage-specific chromosomal aberrations in human adult stem cells.

Authors:  Uri Ben-David; Yoav Mayshar; Nissim Benvenisty
Journal:  Cell Stem Cell       Date:  2011-08-05       Impact factor: 24.633

3.  Nucleotide deficiency promotes genomic instability in early stages of cancer development.

Authors:  Assaf C Bester; Maayan Roniger; Yifat S Oren; Michael M Im; Dan Sarni; Malka Chaoat; Aaron Bensimon; Gideon Zamir; Donna S Shewach; Batsheva Kerem
Journal:  Cell       Date:  2011-04-29       Impact factor: 41.582

4.  Folate levels modulate oncogene-induced replication stress and tumorigenicity.

Authors:  Noa Lamm; Karin Maoz; Assaf C Bester; Michael M Im; Donna S Shewach; Rotem Karni; Batsheva Kerem
Journal:  EMBO Mol Med       Date:  2015-09       Impact factor: 12.137

Review 5.  Quality control: Genome maintenance in pluripotent stem cells.

Authors:  Uri Weissbein; Nissim Benvenisty; Uri Ben-David
Journal:  J Cell Biol       Date:  2014-01-20       Impact factor: 10.539

6.  A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells.

Authors:  Akshay K Ahuja; Karolina Jodkowska; Federico Teloni; Anna H Bizard; Ralph Zellweger; Raquel Herrador; Sagrario Ortega; Ian D Hickson; Matthias Altmeyer; Juan Mendez; Massimo Lopes
Journal:  Nat Commun       Date:  2016-02-15       Impact factor: 14.919

7.  The presence of extra chromosomes leads to genomic instability.

Authors:  Verena Passerini; Efrat Ozeri-Galai; Mirjam S de Pagter; Neysan Donnelly; Sarah Schmalbrock; Wigard P Kloosterman; Batsheva Kerem; Zuzana Storchová
Journal:  Nat Commun       Date:  2016-02-15       Impact factor: 14.919

8.  Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells.

Authors:  Sergio Ruiz; Andres J Lopez-Contreras; Mathieu Gabut; Rosa M Marion; Paula Gutierrez-Martinez; Sabela Bua; Oscar Ramirez; Iñigo Olalde; Sara Rodrigo-Perez; Han Li; Tomas Marques-Bonet; Manuel Serrano; Maria A Blasco; Nizar N Batada; Oscar Fernandez-Capetillo
Journal:  Nat Commun       Date:  2015-08-21       Impact factor: 14.919

9.  Replication stress links structural and numerical cancer chromosomal instability.

Authors:  Rebecca A Burrell; Sarah E McClelland; David Endesfelder; Petra Groth; Marie-Christine Weller; Nadeem Shaikh; Enric Domingo; Nnennaya Kanu; Sally M Dewhurst; Eva Gronroos; Su Kit Chew; Andrew J Rowan; Arne Schenk; Michal Sheffer; Michael Howell; Maik Kschischo; Axel Behrens; Thomas Helleday; Jiri Bartek; Ian P Tomlinson; Charles Swanton
Journal:  Nature       Date:  2013-02-28       Impact factor: 49.962

10.  Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells.

Authors:  Uri Ben-David; Gal Arad; Uri Weissbein; Berhan Mandefro; Adva Maimon; Tamar Golan-Lev; Kavita Narwani; Amander T Clark; Peter W Andrews; Nissim Benvenisty; Juan Carlos Biancotti
Journal:  Nat Commun       Date:  2014-09-08       Impact factor: 14.919
  10 in total
  1 in total

Review 1.  Histones on fire: the effect of Dun1 and Mrc1 on origin firing and replication of hyper-acetylated genomes.

Authors:  Lihi Gershon; Martin Kupiec
Journal:  Curr Genet       Date:  2021-03-14       Impact factor: 3.886
  1 in total

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