Literature DB >> 21816361

Large-scale analysis reveals acquisition of lineage-specific chromosomal aberrations in human adult stem cells.

Uri Ben-David1, Yoav Mayshar, Nissim Benvenisty.   

Abstract

In this study, we assessed the genetic integrity of over 400 samples of human multipotent stem cells using gene expression data sets. Our analysis reveals that neural and mesenchymal stem cells acquire characteristic large chromosomal aberrations at a similar, or somewhat lower, frequency to that seen in pluripotent stem cells, sometimes within a few passages in culture. Some of the identified chromosomal abnormalities can also be detected in human tumors of the respective tissues.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21816361     DOI： 10.1016/j.stem.2011.06.013

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  94 in total

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10.  Passage number is a major contributor to genomic structural variations in mouse iPSCs.

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