Gowri Sayi Prasad1, Sayi Prasad2, Ashok Bhupali2, Ajit N Patil1, Kanishtha Parashar1. 1. Department of Obstetrics and Gynaecology, Dr. D. Y. Patil Hospital and Research Center, Kadamwadi, Kolhapur, Maharashtra 416003 India. 2. Apple Saraswati Multispeciality Hospital and Research Center, Kolhapur, Maharashtra India.
Abstract
PURPOSE: HEV infection, a major public health concern, is known to cause large-scale epidemic and sporadic cases of acute viral hepatitis in developing countries. The infection occurs primarily in young adults and is generally mild and self-limiting; however, the case fatality rate is reportedly higher among women, especially during the second or third trimesters of pregnancy. METHODS: This study, a prospective observational study, was conducted at the Dr. D. Y. Patil Medical College Hospital and Apple Saraswati Multispeciality hospital, in Kolhapur for over a period of 3 years (Jan 2010 to Jan 2013) to find out the prevalence and clinical outcome in a series of HEV-infected pregnant women. RESULTS: A total of fifty-five symptomatic Anti-HEV IgM-positive women were included, and the maternal-fetal outcome was analyzed. The maternal mortality was 5 % including one antenatal death. Prematurity (80 %) and PROM (11 %) were the commonest fetal complications noted with a vertical transmission rate of 28 %. CONCLUSION: Variations in maternal morbidity and mortality between different studies indicate a need to subtype the viral genotype according to its virulence and morbidity.
PURPOSE: HEV infection, a major public health concern, is known to cause large-scale epidemic and sporadic cases of acute viral hepatitis in developing countries. The infection occurs primarily in young adults and is generally mild and self-limiting; however, the case fatality rate is reportedly higher among women, especially during the second or third trimesters of pregnancy. METHODS: This study, a prospective observational study, was conducted at the Dr. D. Y. Patil Medical College Hospital and Apple Saraswati Multispeciality hospital, in Kolhapur for over a period of 3 years (Jan 2010 to Jan 2013) to find out the prevalence and clinical outcome in a series of HEV-infected pregnant women. RESULTS: A total of fifty-five symptomatic Anti-HEV IgM-positive women were included, and the maternal-fetal outcome was analyzed. The maternal mortality was 5 % including one antenatal death. Prematurity (80 %) and PROM (11 %) were the commonest fetal complications noted with a vertical transmission rate of 28 %. CONCLUSION: Variations in maternal morbidity and mortality between different studies indicate a need to subtype the viral genotype according to its virulence and morbidity.
Authors: Sonia K Stoszek; Ronald E Engle; Mohamed Abdel-Hamid; Nabiel Mikhail; Fatma Abdel-Aziz; Ahmed Medhat; Alan D Fix; Suzanne U Emerson; Robert H Purcell; G Thomas Strickland Journal: Trans R Soc Trop Med Hyg Date: 2005-10-28 Impact factor: 2.184
Authors: S A Tsarev; T S Tsareva; S U Emerson; P O Yarbough; L J Legters; T Moskal; R H Purcell Journal: J Med Virol Date: 1994-06 Impact factor: 2.327