INTRODUCTION: Acute liver failure due to acute hepatitis E carries a high mortality. METHODS: Clinical and laboratory parameters of 42 pregnant women (median age 25.5 years) with acute liver failure due to acute hepatitis E were retrospectively analyzed. RESULTS: 22 women delivered, whereas pregnancy continued in 20 women. The maternal mortality in these two groups was similar (9/22 [41%] versus 14/20 [70%], p=0.056). However, in patients with grade I, II or III hepatic encephalopathy, delivery of fetus was associated with reduced mortality in those who delivered as against those who continued pregnancy (5/16 (31%) vs. 13/20 (65%), p=0.046). On multivariate analysis, higher grade of encephalopathy at admission was associated with risk of death (p=0.005). CONCLUSION: Mortality in pregnant women with acute liver failure with acute hepatitis E is high, especially in patients who present with higher grades of encephalopathy.
INTRODUCTION:Acute liver failure due to acute hepatitis E carries a high mortality. METHODS: Clinical and laboratory parameters of 42 pregnant women (median age 25.5 years) with acute liver failure due to acute hepatitis E were retrospectively analyzed. RESULTS: 22 women delivered, whereas pregnancy continued in 20 women. The maternal mortality in these two groups was similar (9/22 [41%] versus 14/20 [70%], p=0.056). However, in patients with grade I, II or III hepatic encephalopathy, delivery of fetus was associated with reduced mortality in those who delivered as against those who continued pregnancy (5/16 (31%) vs. 13/20 (65%), p=0.046). On multivariate analysis, higher grade of encephalopathy at admission was associated with risk of death (p=0.005). CONCLUSION: Mortality in pregnant women with acute liver failure with acute hepatitis E is high, especially in patients who present with higher grades of encephalopathy.
Authors: Alain B Labrique; K Zaman; Zahid Hossain; Parimalendu Saha; Mohammad Yunus; Anowar Hossain; John R Ticehurst; Kenrad E Nelson Journal: Am J Epidemiol Date: 2010-08-26 Impact factor: 4.897
Authors: Emily S Gurley; Amal K Halder; Peter K Streatfield; Hossain M S Sazzad; Tarique M Nurul Huda; M Jahangir Hossain; Stephen P Luby Journal: Am J Public Health Date: 2012-10-18 Impact factor: 9.308
Authors: Andrew A Adjei; Yao Tettey; John T Aviyase; Clement Adu-Gyamfi; Samuel Obed; Julius A A Mingle; Patrick F Ayeh-Kumi; Theophilus K Adiku Journal: Virol J Date: 2009-07-20 Impact factor: 4.099