BACKGROUND: The objective of the study was to analyze a potential association between cognitive functions and thyroid status in postmenopausal women with different polymorphisms of the apolipoprotein E gene (APOE). METHODS: The examined population included 402 postmenopausal women from south-eastern Poland. The evaluation of cognitive functions was made with the use of the diagnostic Central Nervous System-Vital Signs equipment (Polish version). Multiplex polymerase chain reactions were performed to assess APOE polymorphisms. The thyroid hormone tests were assessed by an accredited laboratory. RESULTS AND CONCLUSION: Lower results of cognitive functions were associated with the presence of the ε4 APOE allele in postmenopausal women. The ε4 APOE polymorphism was associated with a higher concentration of thyroid-stimulating hormone and lower concentrations of free triiodothyronine and total triiodothyronine.
BACKGROUND: The objective of the study was to analyze a potential association between cognitive functions and thyroid status in postmenopausal women with different polymorphisms of the apolipoprotein E gene (APOE). METHODS: The examined population included 402 postmenopausal women from south-eastern Poland. The evaluation of cognitive functions was made with the use of the diagnostic Central Nervous System-Vital Signs equipment (Polish version). Multiplex polymerase chain reactions were performed to assess APOE polymorphisms. The thyroid hormone tests were assessed by an accredited laboratory. RESULTS AND CONCLUSION: Lower results of cognitive functions were associated with the presence of the ε4 APOE allele in postmenopausal women. The ε4 APOE polymorphism was associated with a higher concentration of thyroid-stimulating hormone and lower concentrations of free triiodothyronine and total triiodothyronine.
Authors: Matthew G Pontifex; Anneloes Martinsen; Rasha N M Saleh; Glenn Harden; Chris Fox; Michael Muller; David Vauzour; Anne-Marie Minihane Journal: Nutrients Date: 2022-04-19 Impact factor: 6.706
Authors: Elizabeth E Blue; Joshua C Bis; Michael O Dorschner; Debby W Tsuang; Sandra M Barral; Gary Beecham; Jennifer E Below; William S Bush; Mariusz Butkiewicz; Carlos Cruchaga; Anita DeStefano; Lindsay A Farrer; Alison Goate; Jonathan Haines; Jim Jaworski; Gyungah Jun; Brian Kunkle; Amanda Kuzma; Jenny J Lee; Kathryn L Lunetta; Yiyi Ma; Eden Martin; Adam Naj; Alejandro Q Nato; Patrick Navas; Hiep Nguyen; Christiane Reitz; Dolly Reyes; William Salerno; Gerard D Schellenberg; Sudha Seshadri; Harkirat Sohi; Timothy A Thornton; Otto Valadares; Cornelia van Duijn; Badri N Vardarajan; Li-San Wang; Eric Boerwinkle; Josée Dupuis; Margaret A Pericak-Vance; Richard Mayeux; Ellen M Wijsman Journal: Dement Geriatr Cogn Disord Date: 2018-02-27 Impact factor: 2.959