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Literature DB >> 27637396

Role of Metabolomics in Traumatic Brain Injury Research.

Stephanie M Wolahan¹, Daniel Hirt¹, Daniel Braas², Thomas C Glenn³.

Abstract

Metabolomics is an important member of the omics community in that it defines which small molecules may be responsible for disease states. This article reviews the essential principles of metabolomics from specimen preparation, chemical analysis, to advanced statistical methods. Metabolomics in traumatic brain injury has so far been underutilized. Future metabolomics-based studies focused on the diagnoses, prognoses, and treatment effects need to be conducted across all types of traumatic brain injury.

Entities: Chemical Disease Gene Mutation Species

Keywords: Biomarkers; Metabolism; Principal component analysis; Small molecules; Spectroscopy

Mesh：

Year: 2016 PMID： 27637396 PMCID： PMC5028126 DOI： 10.1016/j.nec.2016.05.006

Source DB: PubMed Journal: Neurosurg Clin N Am ISSN： 1042-3680 Impact factor: 2.509

40 in total

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Authors: Thomas C Glenn; Neil A Martin; David L McArthur; David A Hovda; Paul Vespa; Matthew L Johnson; Michael A Horning; George A Brooks
Journal: J Neurotrauma Date: 2015-03-11 Impact factor: 5.269

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Authors: Thomas C Glenn; Neil A Martin; Michael A Horning; David L McArthur; David A Hovda; Paul Vespa; George A Brooks
Journal: J Neurotrauma Date: 2015-03-31 Impact factor: 5.269

8. Transforming research and clinical knowledge in traumatic brain injury pilot: multicenter implementation of the common data elements for traumatic brain injury.

Authors: John K Yue; Mary J Vassar; Hester F Lingsma; Shelly R Cooper; David O Okonkwo; Alex B Valadka; Wayne A Gordon; Andrew I R Maas; Pratik Mukherjee; Esther L Yuh; Ava M Puccio; David M Schnyer; Geoffrey T Manley
Journal: J Neurotrauma Date: 2013-09-24 Impact factor: 5.269

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Authors: Cameron B Jeter; Georgene W Hergenroeder; Norman H Ward; Anthony N Moore; Pramod K Dash
Journal: J Neurotrauma Date: 2013-04-06 Impact factor: 5.269

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Authors: Peter Hutchinson; Kristine O'Phelan
Journal: Neurocrit Care Date: 2014-12 Impact factor: 3.210

7 in total

1. Metabolomics and Precision Medicine in Trauma: The State of the Field.

Authors: Sudha P Jayaraman; Rahul J Anand; Jonathan H DeAntonio; Martin Mangino; Michel B Aboutanos; Vigneshwar Kasirajan; Rao R Ivatury; Alex B Valadka; Olena Glushakova; Ronald L Hayes; Lorin M Bachmann; Gretchen M Brophy; Daniel Contaifer; Urszula O Warncke; Donald F Brophy; Dayanjan S Wijesinghe
Journal: Shock Date: 2018-07 Impact factor: 3.454

2. Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury.

Authors: Fanuel T Hagos; Philip E Empey; Pengcheng Wang; Xiaochao Ma; Samuel M Poloyac; Hülya Bayir; Patrick M Kochanek; Michael J Bell; Robert S B Clark
Journal: Crit Care Med Date: 2018-09 Impact factor: 7.598

3. Plasma metabolomics profiles in rats with acute traumatic brain injury.

Authors: Fei Zheng; Zi-An Xia; Yi-Fu Zeng; Jie-Kun Luo; Peng Sun; Han-Jin Cui; Yang Wang; Tao Tang; Yan-Tao Zhou
Journal: PLoS One Date: 2017-08-03 Impact factor: 3.240

Review 4. Current and Future Applications of Biomedical Engineering for Proteomic Profiling: Predictive Biomarkers in Neuro-Traumatology.

Authors: Mario Ganau; Nikolaos Syrmos; Marco Paris; Laura Ganau; Gianfranco K I Ligarotti; Ali Moghaddamjou; Salvatore Chibbaro; Andrea Soddu; Rossano Ambu; Lara Prisco
Journal: Medicines (Basel) Date: 2018-02-05