Karina J Kersbergen1, Antonios Makropoulos2, Paul Aljabar3, Floris Groenendaal1, Linda S de Vries1, Serena J Counsell3, Manon J N L Benders4. 1. Department of Perinatology, Wilhelmina Children's Hospital and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. 2. Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, UK; Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, UK. 3. Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, UK. 4. Department of Perinatology, Wilhelmina Children's Hospital and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, UK. Electronic address: m.benders@umcutrecht.nl.
Abstract
OBJECTIVES: To investigate third-trimester extrauterine brain growth and correlate this with clinical risk factors in the neonatal period, using serially acquired brain tissue volumes in a large, unselected cohort of extremely preterm born infants. STUDY DESIGN: Preterm infants (gestational age <28 weeks) underwent brain magnetic resonance imaging (MRI) at around 30 weeks postmenstrual age and again around term equivalent age. MRIs were segmented in 50 different regions covering the entire brain. Multivariable regression analysis was used to determine the influence of clinical variables on volumes at both scans, as well as on volumetric growth. RESULTS: MRIs at term equivalent age were available for 210 infants and serial data were available for 131 infants. Growth over these 10 weeks was greatest for the cerebellum, with an increase of 258%. Sex, birth weight z-score, and prolonged mechanical ventilation showed global effects on brain volumes on both scans. The effect of brain injury on ventricular size was already visible at 30 weeks, whereas growth data and volumes at term-equivalent age revealed the effect of brain injury on the cerebellum. CONCLUSION: This study provides data about third-trimester extrauterine volumetric brain growth in preterm infants. Both global and local effects of several common clinical risk factors were found to influence serial volumetric measurements, highlighting the vulnerability of the human brain, especially in the presence of brain injury, during this period.
OBJECTIVES: To investigate third-trimester extrauterine brain growth and correlate this with clinical risk factors in the neonatal period, using serially acquired brain tissue volumes in a large, unselected cohort of extremely preterm born infants. STUDY DESIGN: Preterm infants (gestational age <28 weeks) underwent brain magnetic resonance imaging (MRI) at around 30 weeks postmenstrual age and again around term equivalent age. MRIs were segmented in 50 different regions covering the entire brain. Multivariable regression analysis was used to determine the influence of clinical variables on volumes at both scans, as well as on volumetric growth. RESULTS: MRIs at term equivalent age were available for 210 infants and serial data were available for 131 infants. Growth over these 10 weeks was greatest for the cerebellum, with an increase of 258%. Sex, birth weight z-score, and prolonged mechanical ventilation showed global effects on brain volumes on both scans. The effect of brain injury on ventricular size was already visible at 30 weeks, whereas growth data and volumes at term-equivalent age revealed the effect of brain injury on the cerebellum. CONCLUSION: This study provides data about third-trimester extrauterine volumetric brain growth in preterm infants. Both global and local effects of several common clinical risk factors were found to influence serial volumetric measurements, highlighting the vulnerability of the human brain, especially in the presence of brain injury, during this period.
Authors: N H P Claessens; N Khalili; I Isgum; H Ter Heide; T J Steenhuis; E Turk; N J G Jansen; L S de Vries; J M P J Breur; R de Heus; M J N L Benders Journal: AJNR Am J Neuroradiol Date: 2019-03-28 Impact factor: 3.825
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Authors: Lillian G Matthews; Brian H Walsh; Clare Knutsen; Jeffrey J Neil; Christopher D Smyser; Cynthia E Rogers; Terrie E Inder Journal: Pediatr Res Date: 2018-02-07 Impact factor: 3.756
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Authors: Mercedes I Beltrán; Jeroen Dudink; Tamara M de Jong; Manon J N L Benders; Agnes van den Hoogen Journal: Pediatr Res Date: 2021-09-10 Impact factor: 3.953
Authors: Maria Luisa Tataranno; Nathalie H P Claessens; Pim Moeskops; Mona C Toet; Karina J Kersbergen; Giuseppe Buonocore; Ivana Išgum; Alexander Leemans; Serena Counsell; Floris Groenendaal; Linda S de Vries; Manon J N L Benders Journal: Pediatr Res Date: 2018-01-17 Impact factor: 3.756
Authors: O De Wel; S Van Huffel; M Lavanga; K Jansen; A Dereymaeker; J Dudink; L Gui; P S Hüppi; L S de Vries; G Naulaers; M J N L Benders; M L Tataranno Journal: Cerebellum Date: 2021-02-02 Impact factor: 3.847
Authors: Ralica Dimitrova; Sophie Arulkumaran; Olivia Carney; Andrew Chew; Shona Falconer; Judit Ciarrusta; Thomas Wolfers; Dafnis Batalle; Lucilio Cordero-Grande; Anthony N Price; Rui P A G Teixeira; Emer Hughes; Alexia Egloff; Jana Hutter; Antonios Makropoulos; Emma C Robinson; Andreas Schuh; Katy Vecchiato; Johannes K Steinweg; Russell Macleod; Andre F Marquand; Grainne McAlonan; Mary A Rutherford; Serena J Counsell; Stephen M Smith; Daniel Rueckert; Joseph V Hajnal; Jonathan O'Muircheartaigh; A David Edwards Journal: Cereb Cortex Date: 2021-07-05 Impact factor: 5.357