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Literature DB >> 27634198

Novel blood-brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging.

Xiaolei Wang¹, Miho Emoto², Yusuke Miyake³, Kaori Itto¹, Shu Xu¹, Hirotada Fujii², Hiroshi Hirata³, Hirokazu Arimoto⁴.

Abstract

A novel blood-brain barrier (BBB)-permeable compound 10 was discovered, wherein the nitroxide moiety was linked to a nicotine acetylcholine receptor ligand. It was applied as a probe for electron paramagnetic resonance (EPR) imaging of the mouse brain. The results demonstrated that the newly synthesized compound 10 exhibited BBB permeability. These findings provide an essential discovery for in vivo EPR imaging.

Entities: Chemical Species

Keywords: Blood–brain barrier permeable; EPR brain imaging; Nitroxide; Spin probe

Mesh：

Substances：
Spin Labels

Year: 2016 PMID： 27634198 DOI： 10.1016/j.bmcl.2016.09.010

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

4 in total

1. Modular imaging system: Rapid scan EPR at 800 MHz.

Authors: Oxana Tseytlin; Priyaankadevi Guggilapu; Andrey A Bobko; Hussien AlAhmad; Xuan Xu; Boris Epel; Ryan O'Connell; Emily H Hoblitzell; Timothy D Eubank; Valery V Khramtsov; Benoit Driesschaert; Eiad Kazkaz; Mark Tseytlin
Journal: J Magn Reson Date: 2019-06-08 Impact factor: 2.229

Novel blood-brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging.

1. Modular imaging system: Rapid scan EPR at 800 MHz.

2. Rapid Scan EPR imaging as a Tool for Magnetic Field Mapping.

3. High fidelity triangular sweep of the magnetic field for millisecond scan EPR imaging.

Review 4. In vivo electron paramagnetic resonance oximetry and applications in the brain.

Novel blood-brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging.

1. Modular imaging system: Rapid scan EPR at 800 MHz.

2. Rapid Scan EPR imaging as a Tool for Magnetic Field Mapping.

3. High fidelity triangular sweep of the magnetic field for millisecond scan EPR imaging.

Review 4. In vivo electron paramagnetic resonance oximetry and applications in the brain.

1. Modular imaging system: Rapid scan EPR at 800 MHz.