Caroline Gastebois1, Clément Villars1, Jocelyne Drai1,2, Emmanuelle Canet-Soulas1, Stéphane Blanc3, Audrey Bergouignan3,4, Etienne Lefai1, Chantal Simon5,6. 1. CARMEN, INSERM U1060, University of Lyon 1, INRA1235, CRNH-RA, 69600, Oullins, France. 2. Laboratory of Biochemistry, Hospices Civils de Lyon, 69600, Oullins, France. 3. IPHC CNRS, UMR 7178, University of Strasbourg, 67087, Strasbourg, France. 4. Division of Endocrinology, Metabolism and Diabetes, Anschutz Health and Wellness Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. 5. CARMEN, INSERM U1060, University of Lyon 1, INRA1235, CRNH-RA, 69600, Oullins, France. chantal.simon@univ-lyon1.fr. 6. Service d'Endocrinologie, Diabète, Nutrition, Centre Hospitalier Lyon Sud, 165 Chemin du Grand Revoyet, 69310, Pierre Benite, France. chantal.simon@univ-lyon1.fr.
Abstract
PURPOSE: To delineate the direct effect of physical activity on adiponectin metabolism, we investigated the impact of contrasted physical activity changes, independent of body mass changes, on adiponectin plasma concentration and muscle sensitivity in lean and overweight adult males. METHODS:Eleven physically active lean men (70.6 ± 2.1 kg) were subjected to 1-month detraining; 9 sedentary lean men (73.1 ± 3.3 kg); and 11 sedentary overweight men (97.5 ± 3.0 kg) participated in a 2-monthaerobic-exercise training program. Diet was controlled to maintain stable energy balance. Body composition, VO2peak, circulating adiponectin, adipose and muscle tissue adiponectin, muscle adiponectin receptors, and APPL1 mRNAs were measured before and after the interventions. RESULTS: At baseline, plasma high-molecular-weight adiponectin concentration was lower in both active lean (5.44 ± 0.58 µg/mL) and sedentary overweight (5.30 ± 1.06 µg/mL) than in sedentary lean participants (7.44 ± 1.06 µg/mL; both p < 0.05). Training reduced total and high-molecular-weight adiponectin concentrations by, respectively, -32 and -42 % in sedentary lean, and -26 and -35 % in sedentary overweight, while detraining increased them by +25 and +27 % in active lean participants. Total and high-molecular-weight adiponectin changes were inversely correlated with VO2peak changes (respectively, R 2 = 0.45, R 2 = 0.59; both p < 0.001) and positively with changes in fasting plasma insulin (both p < 0.05). Muscle and adipose tissue adiponectin mRNA did not differ between groups and with interventions. Muscle AdipoR2 and APPL1 mRNAs were lower in sedentary groups compared with the active group; and were positively associated with VO2peak and inversely with fasting plasma insulin concentration. CONCLUSION:Plasma adiponectin concentration is inversely correlated with aerobic capacity. Future investigations will need to confirm the contribution of changes in muscle adiponectin sensitivity.
RCT Entities:
PURPOSE: To delineate the direct effect of physical activity on adiponectin metabolism, we investigated the impact of contrasted physical activity changes, independent of body mass changes, on adiponectin plasma concentration and muscle sensitivity in lean and overweight adult males. METHODS: Eleven physically active lean men (70.6 ± 2.1 kg) were subjected to 1-month detraining; 9 sedentary lean men (73.1 ± 3.3 kg); and 11 sedentary overweight men (97.5 ± 3.0 kg) participated in a 2-month aerobic-exercise training program. Diet was controlled to maintain stable energy balance. Body composition, VO2peak, circulating adiponectin, adipose and muscle tissue adiponectin, muscle adiponectin receptors, and APPL1 mRNAs were measured before and after the interventions. RESULTS: At baseline, plasma high-molecular-weight adiponectin concentration was lower in both active lean (5.44 ± 0.58 µg/mL) and sedentary overweight (5.30 ± 1.06 µg/mL) than in sedentary lean participants (7.44 ± 1.06 µg/mL; both p < 0.05). Training reduced total and high-molecular-weight adiponectin concentrations by, respectively, -32 and -42 % in sedentary lean, and -26 and -35 % in sedentary overweight, while detraining increased them by +25 and +27 % in active lean participants. Total and high-molecular-weight adiponectin changes were inversely correlated with VO2peak changes (respectively, R 2 = 0.45, R 2 = 0.59; both p < 0.001) and positively with changes in fasting plasma insulin (both p < 0.05). Muscle and adipose tissue adiponectin mRNA did not differ between groups and with interventions. Muscle AdipoR2 and APPL1 mRNAs were lower in sedentary groups compared with the active group; and were positively associated with VO2peak and inversely with fasting plasma insulin concentration. CONCLUSION: Plasma adiponectin concentration is inversely correlated with aerobic capacity. Future investigations will need to confirm the contribution of changes in muscle adiponectin sensitivity.
Entities:
Keywords:
Adiponectin receptors; Aerobic fitness; Body weight; Exercise; Multimeric forms
Authors: Jan Polak; Eva Klimcakova; Cedric Moro; Nathalie Viguerie; Michel Berlan; Jindriska Hejnova; Blanka Richterova; Ivan Kraus; Dominique Langin; Vladimir Stich Journal: Metabolism Date: 2006-10 Impact factor: 8.694
Authors: Javier Ibáñez; Mikel Izquierdo; Cristina Martínez-Labari; Francisco Ortega; Ana Grijalba; Luis Forga; Fernando Idoate; Marisol García-Unciti; José M Fernández-Real; Esteban M Gorostiaga Journal: Obesity (Silver Spring) Date: 2009-08-27 Impact factor: 5.002
Authors: Y Arita; S Kihara; N Ouchi; M Takahashi; K Maeda; J Miyagawa; K Hotta; I Shimomura; T Nakamura; K Miyaoka; H Kuriyama; M Nishida; S Yamashita; K Okubo; K Matsubara; M Muraguchi; Y Ohmoto; T Funahashi; Y Matsuzawa Journal: Biochem Biophys Res Commun Date: 1999-04-02 Impact factor: 3.575
Authors: Marco Túlio de Mello; Aline de Piano; June Carnier; Priscila de Lima Sanches; Fabíola Alvise Corrêa; Lian Tock; Regina M Y Ernandes; Sérgio Tufik; Ana R Dâmaso Journal: J Clin Hypertens (Greenwich) Date: 2010-11-08 Impact factor: 3.738
Authors: Joseph M Rutkowski; Nils Halberg; Qiong A Wang; William L Holland; Jonathan Y Xia; Philipp E Scherer Journal: Cardiovasc Diabetol Date: 2014-02-20 Impact factor: 9.951
Authors: Carolina P Celestrin; Guilherme Z Rocha; Angelica M Stein; Dioze Guadagnini; Rafael M Tadelle; Mario J A Saad; Alexandre G Oliveira Journal: Eur Rev Aging Phys Act Date: 2020-08-26 Impact factor: 3.878
Authors: Ali Ataeinosrat; Marjan Mosalman Haghighi; Hossein Abednatanzi; Mohammad Soltani; Abbass Ghanbari-Niaki; Akbar Nouri-Habashi; Sadegh Amani-Shalamzari; Ali Mossayebi; Mitra Khademosharie; Kelly E Johnson; Trisha A VanDusseldorp; Ayoub Saeidi; Hassane Zouhal Journal: Front Physiol Date: 2022-02-21 Impact factor: 4.566