Jing Yu1, Qing Xu1, Jia-Cheng Song1, Yan Li1, Xin Dai1, Dong-Ya Huang2, Ling Zhang1, Yang Li3, Hai-Bin Shi4. 1. Department of Radiology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing, 210029, China. 2. Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 3. Department of Pathology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 4. Department of Radiology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing, 210029, China. shihb@njmu.edu.cn.
Abstract
OBJECTIVES: To evaluate the feasibility and value of diffusion kurtosis (DK) imaging in assessing treatment response to neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). METHODS: Forty-one patients were included. All patients underwent pre- and post-CRT DCE-MRI on a 3.0-Tesla MRI scanner. Imaging indices (D app , K app and ADC values) were measured. Change value (∆X) and change ratio (r∆X) were calculated. Pathological tumour regression grade scores (Mandard) were the standard reference (good responders: pTRG 1-2; poor responders: pTRG 3-5). Diagnostic performance was compared using ROC analysis. RESULTS: For the pre-CRT measurements, pre-D app-10th was significantly lower in the good responder group than that of the poor responder group (p = 0.036). For assessing treatment response to neoadjuvant CRT, pre-D app-10th resulted in AUCs of 0.753 (p = 0.036) with a sensitivity of 66.67 % and a specificity of 77.78 %. The r∆D app had a relatively high AUC (0.859) and high sensitivity (100 %) compared with other image indices. CONCLUSIONS: DKI is feasible for selecting good responders for neoadjuvant CRT for LARC. KEY POINTS: • LARC responded well after neoadjuvant chemoradiotherapy with lower pre-D app-10th . • LARC responded well with greater increases in mean ADC and D app . • The change ratio of D app (r∆D app ) had a relatively better diagnostic performance.
OBJECTIVES: To evaluate the feasibility and value of diffusion kurtosis (DK) imaging in assessing treatment response to neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). METHODS: Forty-one patients were included. All patients underwent pre- and post-CRT DCE-MRI on a 3.0-Tesla MRI scanner. Imaging indices (D app , K app and ADC values) were measured. Change value (∆X) and change ratio (r∆X) were calculated. Pathological tumour regression grade scores (Mandard) were the standard reference (good responders: pTRG 1-2; poor responders: pTRG 3-5). Diagnostic performance was compared using ROC analysis. RESULTS: For the pre-CRT measurements, pre-D app-10th was significantly lower in the good responder group than that of the poor responder group (p = 0.036). For assessing treatment response to neoadjuvant CRT, pre-D app-10th resulted in AUCs of 0.753 (p = 0.036) with a sensitivity of 66.67 % and a specificity of 77.78 %. The r∆D app had a relatively high AUC (0.859) and high sensitivity (100 %) compared with other image indices. CONCLUSIONS: DKI is feasible for selecting good responders for neoadjuvant CRT for LARC. KEY POINTS: • LARC responded well after neoadjuvant chemoradiotherapy with lower pre-D app-10th . • LARC responded well with greater increases in mean ADC and D app . • The change ratio of D app (r∆D app ) had a relatively better diagnostic performance.
Authors: Daniela Musio; Francesca De Felice; Anna Lisa Magnante; Maria Ciolina; Carlo Nicola De Cecco; Marco Rengo; Adriano Redler; Andrea Laghi; Nicola Raffetto; Vincenzo Tombolini Journal: Biomed Res Int Date: 2013-07-10 Impact factor: 3.411
Authors: David D B Bates; Jennifer S Golia Pernicka; James L Fuqua; Viktoriya Paroder; Iva Petkovska; Junting Zheng; Marinela Capanu; Juliana Schilsky; Marc J Gollub Journal: Abdom Radiol (NY) Date: 2020-02