Yeo Jin Kim1, Hee Jin Kim1, Jae-Hyun Park1, Seonwoo Kim1, Sook-Young Woo1, Ki-Chang Kwak1, Jong Min Lee1, Na-Yeon Jung1, Jae Seung Kim1, Yearn Seong Choe1, Kyung-Han Lee1, Seung Hwan Moon1, Jae-Hong Lee1, Yun Joong Kim1, David J Werring1, Duk L Na1, Sang Won Seo2. 1. From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea. 2. From the Department of Neurology (Y.J.K.), Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon; Departments of Neurology (H.J.K., D.L.N., S.W.S.) and Nuclear Medicine (Y.S.C., K.-H.L., S.H.M.), Sungkyunkwan University School of Medicine, and Neuroscience Center (H.J.K., D.L.N., S.W.S.), Samsung Medical Center, Seoul; Department of Neurology (J.-H.P.), Semyeong Christianity Hospital, Pohang; Biostatistics Team (S.K., S.-Y.W.), Samsung Biomedical Research Institute; Department of Biomedical Engineering (K.-C.K., J.M.L.), Hanyang University, Seoul; Department of Neurology (N.-Y.J.), Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan; Departments of Nuclear Medicine (J.S.K.) and Neurology (J.-H.L.), University of Ulsan College of Medicine, Asan Medical Center, Seoul; Department of Neurology (Y.J.K.), Ilsong Institute of Life Science, Hallym University, Anyang, Korea; Stroke Research Centre (D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK; and Departments of Health Sciences and Technology (D.L.N.) and Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea. sangwonseo@empal.com.
Abstract
OBJECTIVE: To determine whether amyloid and hypertensive cerebral small vessel disease (hCSVD) changes synergistically affect the progression of lobar microbleeds in patients with subcortical vascular mild cognitive impairment (svMCI). METHODS: Among 72 patients with svMCI who underwent brain MRI and [11C] Pittsburgh compound B (PiB)-PET, 52 (72.2%) completed the third year of follow-up. These patients were evaluated by annual neuropsychological testing, brain MRI, and follow-up PiB-PET. RESULTS: Over 3 years, 31 of 52 patients (59.6%) had incident cerebral microbleeds (CMBs) in the lobar and deep regions. Both baseline and longitudinal changes in lacune numbers were associated with increased numbers of lobar and deep microbleeds, while baseline and longitudinal changes in PiB uptake ratio were associated only with the progression of lobar microbleeds, especially in the temporal, parietal, and occipital areas. Regional white matter hyperintensity severity was also associated with regional lobar CMBs in the parietal and occipital regions. There were interactive effects between baseline and longitudinal lacune number and PiB retention on lobar microbleed progression. Increased lobar, but not deep, CMBs were associated with decreased scores in the digit span backward task and Rey-Osterrieth Complex Figure Test. CONCLUSIONS: Our findings suggest that amyloid-related pathology and hCSVD have synergistic effects on the progression of lobar microbleeds, providing new clinical insight into the interaction between amyloid burden and hCSVD on CMB progression and cognitive decline with implications for developing effective prevention strategies.
OBJECTIVE: To determine whether amyloid and hypertensive cerebral small vessel disease (hCSVD) changes synergistically affect the progression of lobar microbleeds in patients with subcortical vascular mild cognitive impairment (svMCI). METHODS: Among 72 patients with svMCI who underwent brain MRI and [11C] Pittsburgh compound B (PiB)-PET, 52 (72.2%) completed the third year of follow-up. These patients were evaluated by annual neuropsychological testing, brain MRI, and follow-up PiB-PET. RESULTS: Over 3 years, 31 of 52 patients (59.6%) had incident cerebral microbleeds (CMBs) in the lobar and deep regions. Both baseline and longitudinal changes in lacune numbers were associated with increased numbers of lobar and deep microbleeds, while baseline and longitudinal changes in PiB uptake ratio were associated only with the progression of lobar microbleeds, especially in the temporal, parietal, and occipital areas. Regional white matter hyperintensity severity was also associated with regional lobar CMBs in the parietal and occipital regions. There were interactive effects between baseline and longitudinal lacune number and PiB retention on lobar microbleed progression. Increased lobar, but not deep, CMBs were associated with decreased scores in the digit span backward task and Rey-Osterrieth Complex Figure Test. CONCLUSIONS: Our findings suggest that amyloid-related pathology and hCSVD have synergistic effects on the progression of lobar microbleeds, providing new clinical insight into the interaction between amyloid burden and hCSVD on CMB progression and cognitive decline with implications for developing effective prevention strategies.
Authors: Hyemin Jang; Young Kyoung Jang; Hee Jin Kim; David John Werring; Jin San Lee; Yeong Sim Choe; Seongbeom Park; Juyeon Lee; Ko Woon Kim; Yeshin Kim; Soo Hyun Cho; Si Eun Kim; Seung Joo Kim; Andreas Charidimou; Duk L Na; Sang Won Seo Journal: Eur J Nucl Med Mol Imaging Date: 2019-04-02 Impact factor: 9.236
Authors: Young Kyoung Jang; Hee Jin Kim; Jin San Lee; Yeo Jin Kim; Ko Woon Kim; Yeshin Kim; Hyemin Jang; Juyoun Lee; Jong Min Lee; Seung-Joo Kim; Kyung-Ho Yu; Andreas Charidimou; David J Werring; Sung Tae Kim; Duk L Na; Sang Won Seo Journal: Sci Rep Date: 2017-11-22 Impact factor: 4.379
Authors: Ulf R Jensen-Kondering; Caroline Weiler; Patrick Langguth; Naomi Larsen; Charlotte Flüh; Gregor Kuhlenbäumer; Olav Jansen; Nils G Margraf Journal: J Neurol Date: 2020-07-08 Impact factor: 4.849
Authors: Marco Pasi; Andreas Charidimou; Gregoire Boulouis; Eitan Auriel; Alison Ayres; Kristin M Schwab; Joshua N Goldstein; Jonathan Rosand; Anand Viswanathan; Leonardo Pantoni; Steven M Greenberg; M Edip Gurol Journal: Neurology Date: 2017-12-15 Impact factor: 11.800