Yousra M El-Far1, Mahmoud M Zakaria2, Mahmoud M Gabr2, Amal M El Gayar1, Ibrahim M El-Sherbiny3, Laila A Eissa1. 1. Department of Clinical Biochemistry, Faculty of Pharmacy, Mansoura University, 35516, Egypt. 2. Urology & Nephrology Center, Mansoura, 35516, Egypt. 3. Center for Materials Science, University of Science & Technology, Zewail City of Science & Technology, 6th October City, 12588 Giza, Egypt.
Abstract
AIM: This study aimed to develop a new stable nanoformulation of silymarin (SM) with optimum enhanced oral bioavailability and to evaluate its effect as well as mechanism of action as a superior antidiabetic agent over native SM using streptozotocin-induced diabetic rats. MATERIALS AND METHODS: SM-loaded pluronic nanomicelles (SMnp) were prepared and fully characterized. Biochemical parameters were performed as well as histological, confocal and reverse-transcription polymerase chain reaction studies on pancreatic target tissues. RESULTS & CONCLUSION: SMnp were found to improve significantly the antihyperglycemic, antioxidant and antihyperlipidemic properties as compared with native SM. In addition, SMnp was found to be a more efficient agent over SM in the management of diabetes and its associated complications due to its superior bioavailability in vivo, and the controlled release profile of SM. [Formula: see text].
AIM: This study aimed to develop a new stable nanoformulation of silymarin (SM) with optimum enhanced oral bioavailability and to evaluate its effect as well as mechanism of action as a superior antidiabetic agent over native SM using streptozotocin-induced diabeticrats. MATERIALS AND METHODS:SM-loaded pluronic nanomicelles (SMnp) were prepared and fully characterized. Biochemical parameters were performed as well as histological, confocal and reverse-transcription polymerase chain reaction studies on pancreatic target tissues. RESULTS & CONCLUSION:SMnp were found to improve significantly the antihyperglycemic, antioxidant and antihyperlipidemic properties as compared with native SM. In addition, SMnp was found to be a more efficient agent over SM in the management of diabetes and its associated complications due to its superior bioavailability in vivo, and the controlled release profile of SM. [Formula: see text].
Authors: Mohamed A Shaheen; Samah H Elmeadawy; Fagr B Bazeed; Mohamed M Anees; Noha M Saleh Journal: Drug Deliv Transl Res Date: 2020-04 Impact factor: 4.617
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