Kaisa Ylänen1,2, Anneli Eerola3, Kim Vettenranta4,5, Tuija Poutanen3,6. 1. Department of Pediatrics, Tampere University Hospital, PO BOX 2000, FIN-33521, Tampere, Finland. kaisa@ylanen.fi. 2. University of Tampere, Tampere, Finland. kaisa@ylanen.fi. 3. Department of Pediatrics, Tampere University Hospital, PO BOX 2000, FIN-33521, Tampere, Finland. 4. Hospital for Children and Adolescents, PO BOX 281, FIN-00029 HUS, Helsinki, Finland. 5. University of Helsinki, Helsinki, Finland. 6. University of Tampere, Tampere, Finland.
Abstract
UNLABELLED: Longitudinal motion significantly contributes to the contraction of the ventricles. We studied the left (LV) and right ventricular (RV) longitudinal functions in 75 anthracycline-exposed, long-term childhood cancer survivors and 75 healthy controls with conventional echocardiography, tissue Doppler imaging (TDI), speckle tracking echocardiography (STE) of the mitral and tricuspid annular motion, and real-time three-dimensional echocardiography (RT-3DE). Cardiac magnetic resonance (CMR) imaging was performed on 61 of the survivors. The survivors had lower systolic myocardial velocities in the LV and lower diastolic velocities in both ventricles by TDI than did their healthy peers. The STE-based tissue motion annular displacement (TMAD) values describing the LV and RV systolic longitudinal function (MAD and TAD mid%, respectively) were also lower among the survivors (15.4 ± 2.4 vs. 16.1 ± 2.2 %, p = 0.049 and 22.5 ± 3.0 vs. 23.5 ± 3.0 %, p = 0.035). MAD and TAD mid in millimeters correlated with the respective ventricular volumes measured with RT-3DE or CMR. CONCLUSION: Childhood cancer survivors exposed to low to moderate anthracycline doses had decreased longitudinal systolic and diastolic functions (TDI or STE) compared with healthy controls. The STE-based TMAD is a fast and reproducible method to assess cardiac longitudinal function. What is Known? • High anthracycline doses cause LV dysfunction as evidenced by a decreased ejection fraction. What is new? • Low to moderate anthracycline doses also have a negative impact on the LV and RV longitudinal systolic and diastolic function. • TMAD is a new and fast method to assess the cardiac longitudinal function after anthracycline exposure.
UNLABELLED: Longitudinal motion significantly contributes to the contraction of the ventricles. We studied the left (LV) and right ventricular (RV) longitudinal functions in 75 anthracycline-exposed, long-term childhood cancer survivors and 75 healthy controls with conventional echocardiography, tissue Doppler imaging (TDI), speckle tracking echocardiography (STE) of the mitral and tricuspid annular motion, and real-time three-dimensional echocardiography (RT-3DE). Cardiac magnetic resonance (CMR) imaging was performed on 61 of the survivors. The survivors had lower systolic myocardial velocities in the LV and lower diastolic velocities in both ventricles by TDI than did their healthy peers. The STE-based tissue motion annular displacement (TMAD) values describing the LV and RV systolic longitudinal function (MAD and TAD mid%, respectively) were also lower among the survivors (15.4 ± 2.4 vs. 16.1 ± 2.2 %, p = 0.049 and 22.5 ± 3.0 vs. 23.5 ± 3.0 %, p = 0.035). MAD and TAD mid in millimeters correlated with the respective ventricular volumes measured with RT-3DE or CMR. CONCLUSION: Childhood cancer survivors exposed to low to moderate anthracycline doses had decreased longitudinal systolic and diastolic functions (TDI or STE) compared with healthy controls. The STE-based TMAD is a fast and reproducible method to assess cardiac longitudinal function. What is Known? • High anthracycline doses cause LV dysfunction as evidenced by a decreased ejection fraction. What is new? • Low to moderate anthracycline doses also have a negative impact on the LV and RV longitudinal systolic and diastolic function. • TMAD is a new and fast method to assess the cardiac longitudinal function after anthracycline exposure.
Authors: S R Ommen; R A Nishimura; C P Appleton; F A Miller; J K Oh; M M Redfield; A J Tajik Journal: Circulation Date: 2000-10-10 Impact factor: 29.690
Authors: Benjamin W Eidem; Colin J McMahon; Radha R Cohen; Jin Wu; Irina Finkelshteyn; John P Kovalchin; Nancy A Ayres; Louis I Bezold; E O'Brian Smith; Ricardo H Pignatelli Journal: J Am Soc Echocardiogr Date: 2004-03 Impact factor: 5.251
Authors: Alexander Van De Bruaene; Pieter De Meester; Jens-Uwe Voigt; Marion Delcroix; Agnes Pasquet; Julie De Backer; Michel De Pauw; Robert Naeije; Jean-Luc Vachiéry; Bernard Paelinck; Marielle Morissens; Werner Budts Journal: Am J Cardiol Date: 2012-01-24 Impact factor: 2.778
Authors: Martin Koestenberger; Bert Nagel; William Ravekes; Allen D Everett; Hans Peter Stueger; Bernd Heinzl; Erich Sorantin; Gerhard Cvirn; Andreas Gamillscheg Journal: Clin Res Cardiol Date: 2010-09-12 Impact factor: 5.460
Authors: Martin Koestenberger; William Ravekes; Allen D Everett; Hans Peter Stueger; Bernd Heinzl; Andreas Gamillscheg; Gerhard Cvirn; Arnulf Boysen; Andrea Fandl; Bert Nagel Journal: J Am Soc Echocardiogr Date: 2009-05-07 Impact factor: 5.251
Authors: David E Black; Jen Bryant; Charles Peebles; Keith M Godfrey; Mark Hanson; Joseph J Vettukattil Journal: Cardiol Young Date: 2013-06-27 Impact factor: 1.093
Authors: Eric J Chow; Kasey J Leger; Neel S Bhatt; Daniel A Mulrooney; Colin J Ross; Sanjeev Aggarwal; Neha Bansal; Matthew J Ehrhardt; Saro H Armenian; Jessica M Scott; Borah Hong Journal: Cardiovasc Res Date: 2019-04-15 Impact factor: 10.787
Authors: Richard John Massey; Phoi Phoi Diep; Marta Maria Burman; Anette Borger Kvaslerud; Lorentz Brinch; Svend Aakhus; Lars Gullestad; Ellen Ruud; Jan Otto Beitnes Journal: Open Heart Date: 2021-12
Authors: Rosaria Sofia; Veronica Melita; Antonio De Vita; Antonio Ruggiero; Alberto Romano; Giorgio Attinà; Lisa Birritella; Priscilla Lamendola; Antonella Lombardo; Gaetano Antonio Lanza; Angelica Bibiana Delogu Journal: Front Oncol Date: 2021-05-14 Impact factor: 6.244