Binhao Zhang1, Gang Wei1, Rui Li2, Yanjun Wang1, Jie Yu1, Rui Wang1, Hua Xiao1, Chao Wu1, Chao Leng1, Bixiang Zhang3, Xiao-Ping Chen4. 1. Institute of Hepato-Pancreato-Bililary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. 2. Department of Oncology Center, Wuhan No. 11 Hospital Affiliated to Medical College, Wuhan University of Science and Technology, Wuhan, 430016, China. 3. Institute of Hepato-Pancreato-Bililary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: bixiangzhang@163.com. 4. Institute of Hepato-Pancreato-Bililary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: chenxp@medmail.com.cn.
Abstract
BACKGROUND & AIMS: A new lipid emulsion enriched in n-3 fatty acid has been reported to prevent hepatic inflammation in patients following major surgery. However, the role of n-3 fatty acid-based parenteral nutrition for postoperative patients with cirrhosis-related liver cancer is unclear. We investigated the safety and efficacy of n-3 fatty acid-based parenteral nutrition for cirrhotic patients with liver cancer followed hepatectomy. METHODS: A prospective randomized controlled clinical trial (Registered under ClinicalTrials.gov Identifier no. NCT02321202) was conducted for cirrhotic patients with liver cancer that underwent hepatectomy between March 2010 and September 2013 in our institution. We compared isonitrogenous total parenteral nutrition with 20% Structolipid and 10% n-3 fatty acid (Omegaven, Fresenius-Kabi, Germany) (treatment group) to Structolipid alone (control group) for five days postoperatively, in the absence of enteral nutrition. RESULTS:We enrolled 320 patients, and 312 (97.5%) were included in analysis (155 in the control group and 157 in the treatment group). There was a significant reduction of morbidity and mortality in the treatment group, when compared with the control group (total complications 78 [50.32%] vs. 46 [29.30%]; P < 0.001, total infective complications, 30 [19.35%] vs. 15 [9.55%]; P = 0.014), overall mortality (5 [3.23%] vs. 1 [0.64%]; P = 0.210), and hospital stay (12.56 ± 3.21 d vs. 10.17 ± 3.15 d; P = 0.018). CONCLUSIONS: We found that addition of n-3 fatty acid-based parenteral nutrition significantly improved postoperative recovery for cirrhotic patients with liver cancer following hepatectomy, with a significant reduction in overall mortality and length of hospital stay.
RCT Entities:
BACKGROUND & AIMS: A new lipid emulsion enriched in n-3 fatty acid has been reported to prevent hepatic inflammation in patients following major surgery. However, the role of n-3 fatty acid-based parenteral nutrition for postoperative patients with cirrhosis-related liver cancer is unclear. We investigated the safety and efficacy of n-3 fatty acid-based parenteral nutrition for cirrhoticpatients with liver cancer followed hepatectomy. METHODS: A prospective randomized controlled clinical trial (Registered under ClinicalTrials.gov Identifier no. NCT02321202) was conducted for cirrhoticpatients with liver cancer that underwent hepatectomy between March 2010 and September 2013 in our institution. We compared isonitrogenous total parenteral nutrition with 20% Structolipid and 10% n-3 fatty acid (Omegaven, Fresenius-Kabi, Germany) (treatment group) to Structolipid alone (control group) for five days postoperatively, in the absence of enteral nutrition. RESULTS: We enrolled 320 patients, and 312 (97.5%) were included in analysis (155 in the control group and 157 in the treatment group). There was a significant reduction of morbidity and mortality in the treatment group, when compared with the control group (total complications 78 [50.32%] vs. 46 [29.30%]; P < 0.001, total infective complications, 30 [19.35%] vs. 15 [9.55%]; P = 0.014), overall mortality (5 [3.23%] vs. 1 [0.64%]; P = 0.210), and hospital stay (12.56 ± 3.21 d vs. 10.17 ± 3.15 d; P = 0.018). CONCLUSIONS: We found that addition of n-3 fatty acid-based parenteral nutrition significantly improved postoperative recovery for cirrhoticpatients with liver cancer following hepatectomy, with a significant reduction in overall mortality and length of hospital stay.
Authors: Meredith A Baker; Prathima Nandivada; Paul D Mitchell; Gillian L Fell; Amy Pan; Lorenzo Anez-Bustillos; Duy T Dao; Kathleen M Gura; Vania Nosé; Mark Puder Journal: Surgery Date: 2018-01-19 Impact factor: 3.982
Authors: Lorenzo Pradelli; Konstantin Mayer; Stanislaw Klek; Abdul Jabbar Omar Alsaleh; Richard A C Clark; Martin D Rosenthal; Axel R Heller; Maurizio Muscaritoli Journal: JPEN J Parenter Enteral Nutr Date: 2019-06-27 Impact factor: 4.016
Authors: Seong-Jung Kim; In Ae Chun; Ju-Yeon Cho; Jun Hyung Lee; Jun Lee; Young-Dae Kim; Chan-Guk Park Journal: Medicine (Baltimore) Date: 2022-04-08 Impact factor: 1.817