| Literature DB >> 27608958 |
Sigurd Ziegler1, Mads L Pedersen2, Athanasia M Mowinckel3, Guido Biele4.
Abstract
Attention deficit hyperactivity disorder (ADHD) is characterized by altered decision-making (DM) and reinforcement learning (RL), for which competing theories propose alternative explanations. Computational modelling contributes to understanding DM and RL by integrating behavioural and neurobiological findings, and could elucidate pathogenic mechanisms behind ADHD. This review of neurobiological theories of ADHD describes predictions for the effect of ADHD on DM and RL as described by the drift-diffusion model of DM (DDM) and a basic RL model. Empirical studies employing these models are also reviewed. While theories often agree on how ADHD should be reflected in model parameters, each theory implies a unique combination of predictions. Empirical studies agree with the theories' assumptions of a lowered DDM drift rate in ADHD, while findings are less conclusive for boundary separation. The few studies employing RL models support a lower choice sensitivity in ADHD, but not an altered learning rate. The discussion outlines research areas for further theoretical refinement in the ADHD field. Copyright ÂEntities:
Keywords: Attention deficit hyperactivity disorder; Computational model; Computational psychiatry; Decision-making; Dopamine; Dopamine transfer deficit theory; Drift-diffusion model; Dynamic developmental theory; Moderate brain arousal model; Neurobiology; Noradrenaline; Pathogenesis; Prediction error; Reinforcement learning
Mesh:
Year: 2016 PMID: 27608958 DOI: 10.1016/j.neubiorev.2016.09.002
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN: 0149-7634 Impact factor: 8.989