Literature DB >> 27605873

Immunological battlefield in gastric cancer and role of immunotherapies.

Minyu Wang1, Rita A Busuttil1, Sharon Pattison1, Paul J Neeson1, Alex Boussioutas1.   

Abstract

Like the wars predating the First World War where human foot soldiers were deemed tools in the battlefield against an enemy, so too are the host immune cells of a patient battling a malignant gastric cancer. Indeed, the tumour microenvironment resembles a battlefield, where the patient's immune cells are the defence against invading tumour cells. However, the relationship between different immune components of the host response to cancer is more complex than an "us against them" model. Components of the immune system inadvertently work against the interests of the host and become pro-tumourigenic while other components soldier on against the common enemy - the tumour cell.

Entities:  

Keywords:  Gastric cancer; Immune; Immune therapy; Immunology; Tumour microenvironment

Mesh：

Substances：

Year:  2016        PMID： 27605873      PMCID： PMC4968119          DOI： 10.3748/wjg.v22.i28.6373

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  85 in total

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2.  A First-in-Human Phase I Study of Subcutaneous Outpatient Recombinant Human IL15 (rhIL15) in Adults with Advanced Solid Tumors.

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3.  Lauren classification identifies distinct prognostic value and functional status of intratumoral CD8+ T cells in gastric cancer.

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Journal:  Cancer Immunol Immunother       Date:  2020-03-21       Impact factor: 6.968

4.  Identification of different gene expressions between diffuse- and intestinal-type spheroid-forming gastric cancer cells.

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Review 5.  Pembrolizumab for the treatment of patients with recurrent locally advanced or metastatic gastric or gastroesophageal junction cancer: an evidence-based review of place in therapy.

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Review 7.  A Review of Emerging Biomarkers for Immune Checkpoint Inhibitors in Tumors of the Gastrointestinal Tract.

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8.  Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells.

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Review 9.  Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem Cells.

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