| Literature DB >> 24823638 |
Shicheng Su1, Qiang Liu1, Jingqi Chen2, Jianing Chen1, Fei Chen1, Chonghua He1, Di Huang1, Wei Wu1, Ling Lin3, Wei Huang4, Jin Zhang5, Xiuying Cui4, Fang Zheng4, Haiyan Li1, Herui Yao6, Fengxi Su1, Erwei Song7.
Abstract
The close vicinity of cancer cells undergoing epithelial-mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) at the invasive front of tumors suggests that these two cell type may mutually interact. We show that mesenchymal-like breast cancer cells activate macrophages to a TAM-like phenotype by GM-CSF. Reciprocally, CCL18 from TAMs induces cancer cell EMT, forming a positive feedback loop, in coculture systems and humanized mice. Inhibition of GM-CSF or CCL18 breaks this loop and reduces cancer metastasis. High GM-CSF expression in breast cancer samples is associated with more CCL18(+) macrophages, cancer cell EMT, enhanced metastasis, and reduced patient survival. These findings suggest that a positive feedback loop between GM-CSF and CCL18 is important in breast cancer metastasis.Entities:
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Year: 2014 PMID： 24823638 DOI： 10.1016/j.ccr.2014.03.021
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743