Literature DB >> 27605205

The pol II CTD: new twists in the tail.

Justyna Zaborowska1, Sylvain Egloff2, Shona Murphy1.   

Abstract

The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises conserved heptad repeats, and post-translational modification of the CTD regulates transcription and cotranscriptional RNA processing. Recently, the spatial patterns of modification of the CTD repeats have been investigated, and new functions of CTD modification have been revealed. In addition, there are new insights into the roles of the enzymes that decorate the CTD. We review these new findings and reassess the role of the pol II CTD in the regulation of gene expression.

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Year:  2016        PMID： 27605205     DOI： 10.1038/nsmb.3285

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  90 in total

1.  Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.

Authors:  J B Kim; P A Sharp
Journal:  J Biol Chem       Date:  2001-01-05       Impact factor: 5.157

2.  Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline.

Authors:  Elizabeth Anne Bowman; Christopher Ray Bowman; Jeong H Ahn; William G Kelly
Journal:  Development       Date:  2013-07-31       Impact factor: 6.868

3.  Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation.

Authors:  Shotaro Wani; Ai Sugita; Yoshiaki Ohkuma; Yutaka Hirose
Journal:  J Biochem       Date:  2016-02-26       Impact factor: 3.387

4.  Histone deacetylases and phosphorylated polymerase II C-terminal domain recruit Spt6 for cotranscriptional histone reassembly.

Authors:  Bala Bharathi Burugula; Célia Jeronimo; Rakesh Pathak; Jeffery W Jones; François Robert; Chhabi K Govind
Journal:  Mol Cell Biol       Date:  2014-09-02       Impact factor: 4.272

5.  Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.

Authors:  S-W Grace Cheng; Michael A Kuzyk; Annie Moradian; Taka-Aki Ichu; Vicky C-D Chang; Jerry F Tien; Sarah E Vollett; Malachi Griffith; Marco A Marra; Gregg B Morin
Journal:  Mol Cell Biol       Date:  2012-09-17       Impact factor: 4.272

6.  The C-terminal domain of RNA polymerase II is modified by site-specific methylation.

Authors:  Robert J Sims; Luis Alejandro Rojas; David B Beck; Roberto Bonasio; Roland Schüller; William J Drury; Dirk Eick; Danny Reinberg
Journal:  Science       Date:  2011-04-01       Impact factor: 47.728

7.  Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription.

Authors:  Andres Clemente-Blanco; Nicholas Sen; Maria Mayan-Santos; Maria P Sacristán; Bryony Graham; Adam Jarmuz; Adam Giess; Elizabeth Webb; Laurence Game; Dirk Eick; Avelino Bueno; Matthias Merkenschlager; Luis Aragón
Journal:  Nat Cell Biol       Date:  2011-10-23       Impact factor: 28.824

8.  Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD.

Authors:  Mitsunori Koga; Megumi Hayashi; Daisuke Kaida
Journal:  Nucleic Acids Res       Date:  2015-07-21       Impact factor: 16.971

9.  The Nrd1-Nab3-Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II C-terminal domain.

Authors:  Lidia Vasiljeva; Minkyu Kim; Hannes Mutschler; Stephen Buratowski; Anton Meinhart
Journal:  Nat Struct Mol Biol       Date:  2008-07-27       Impact factor: 15.369

10.  3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells.

Authors:  Lee Davidson; Lisa Muniz; Steven West
Journal:  Genes Dev       Date:  2014-01-29       Impact factor: 11.361
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  88 in total

Review 1.  Phase Separation and Transcription Regulation: Are Super-Enhancers and Locus Control Regions Primary Sites of Transcription Complex Assembly?

Authors:  Aishwarya Gurumurthy; Yong Shen; Eliot M Gunn; Jörg Bungert
Journal:  Bioessays       Date:  2018-11-30       Impact factor: 4.345

Review 2.  Nascent RNA and the Coordination of Splicing with Transcription.

Authors:  Karla M Neugebauer
Journal:  Cold Spring Harb Perspect Biol       Date:  2019-08-01       Impact factor: 10.005

3.  Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment.

Authors:  Weiwei Shan; Jiao Yuan; Zhongyi Hu; Junjie Jiang; Yueying Wang; Nicki Loo; Lingling Fan; Zhaoqing Tang; Tianli Zhang; Mu Xu; Yutian Pan; Jiaqi Lu; Meixiao Long; Janos L Tanyi; Kathleen T Montone; Yi Fan; Xiaowen Hu; Youyou Zhang; Lin Zhang
Journal:  Cell Rep       Date:  2020-07-14       Impact factor: 9.423

4.  Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation.

Authors:  Leah A Gates; Jiejun Shi; Aarti D Rohira; Qin Feng; Bokai Zhu; Mark T Bedford; Cari A Sagum; Sung Yun Jung; Jun Qin; Ming-Jer Tsai; Sophia Y Tsai; Wei Li; Charles E Foulds; Bert W O'Malley
Journal:  J Biol Chem       Date:  2017-07-17       Impact factor: 5.157

5.  Ras and Rho GTPase regulation of Pol II transcription: A shortcut model revisited.

Authors:  Zhi-Liang Zheng
Journal:  Transcription       Date:  2017-05-26

Review 6.  Balanced between order and disorder: a new phase in transcription elongation control and beyond.

Authors:  Huasong Lu; Rongdiao Liu; Qiang Zhou
Journal:  Transcription       Date:  2019-01-31

7.  ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas.

Authors:  Christopher G Abraham; Michael P Ludwig; Zdenek Andrysik; Ahwan Pandey; Molishree Joshi; Matthew D Galbraith; Kelly D Sullivan; Joaquin M Espinosa
Journal:  Cell Rep       Date:  2018-09-18       Impact factor: 9.423

8.  The C-Terminal Domain of RNA Polymerase II Is a Multivalent Targeting Sequence that Supports Drosophila Development with Only Consensus Heptads.

Authors:  Feiyue Lu; Bede Portz; David S Gilmour
Journal:  Mol Cell       Date:  2019-02-11       Impact factor: 17.970

9.  Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.

Authors:  Ibraheem Ali; Diego Garrido Ruiz; Zuyao Ni; Jeffrey R Johnson; Heng Zhang; Pao-Chen Li; Mir M Khalid; Ryan J Conrad; Xinghua Guo; Jinrong Min; Jack Greenblatt; Matthew Jacobson; Nevan J Krogan; Melanie Ott
Journal:  Mol Cell       Date:  2019-05-01       Impact factor: 17.970

Review 10.  Sub1/PC4, a multifaceted factor: from transcription to genome stability.

Authors:  Miguel Garavís; Olga Calvo
Journal:  Curr Genet       Date:  2017-05-31       Impact factor: 3.886
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