Emanuel Dias-Jácome1, Diogo Libânio2, Marta Borges-Canha3, Ana Galaghar4, Pedro Pimentel-Nunes1. 1. CINTESIS, Faculty of Medicine, University of Porto, Portugal. 2. Gastroenterology Department, Oncology Portuguese Institute of Porto, Portugal. 3. Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Portugal. 4. Pathology Department, Oncology Portuguese Institute of Porto, Portugal.
Abstract
BACKGROUND AND AIM: Helicobacter pylori is the strongest risk factor for gastric cancer. However, recent advances in DNA sequencing technology have revealed a complex microbial community in the stomach that could also contribute to the development of gastric cancer. The aim of this study was to present recent scientific evidence regarding the role of non-Helicobacter pylori bacteria in gastric carcinogenesis. METHODS: A systematic review of original articles published in PubMed in the last ten years related to gastric microbiota and gastric cancer in humans was performed. RESULTS: Thirteen original articles were included. The constitution of gastric microbiota appears to be significantly affected by gastric cancer and premalignant lesions. In fact, differences in gastric microbiota have been documented, depending on Helicobacter pylori status and gastric conditions, such as non-atrophic gastritis, intestinal metaplasia and cancer. Gastric carcinogenesis can be associated with an increase in many bacteria (such as Lactobacillus coleohominis, Klebsiella pneumoniae or Acinetobacter baumannii) as well as decrease in others (such as Porphyromonas spp, Neisseria spp, Prevotella pallens or Streptococcus sinensis). However, there is no conclusive data that confirms if these changes in microbiota are a cause or consequence of the process of carcinogenesis. CONCLUSIONS: Even though there is limited evidence in humans, microbiota differences between normal individuals, pre-malignant lesions and gastric cancer could suggest a progressive shift in the constitution of gastric microbiota in carcinogenesis, possibly resulting from a complex cross-talk between gastric microbiota and Helicobacter pylori. However, further studies are needed to elucidate the specific role (if any) of different microorganisms.
BACKGROUND AND AIM: Helicobacter pylori is the strongest risk factor for gastric cancer. However, recent advances in DNA sequencing technology have revealed a complex microbial community in the stomach that could also contribute to the development of gastric cancer. The aim of this study was to present recent scientific evidence regarding the role of non-Helicobacter pylori bacteria in gastric carcinogenesis. METHODS: A systematic review of original articles published in PubMed in the last ten years related to gastric microbiota and gastric cancer in humans was performed. RESULTS: Thirteen original articles were included. The constitution of gastric microbiota appears to be significantly affected by gastric cancer and premalignant lesions. In fact, differences in gastric microbiota have been documented, depending on Helicobacter pylori status and gastric conditions, such as non-atrophic gastritis, intestinal metaplasia and cancer. Gastric carcinogenesis can be associated with an increase in many bacteria (such as Lactobacillus coleohominis, Klebsiella pneumoniae or Acinetobacter baumannii) as well as decrease in others (such as Porphyromonas spp, Neisseria spp, Prevotella pallens or Streptococcus sinensis). However, there is no conclusive data that confirms if these changes in microbiota are a cause or consequence of the process of carcinogenesis. CONCLUSIONS: Even though there is limited evidence in humans, microbiota differences between normal individuals, pre-malignant lesions and gastric cancer could suggest a progressive shift in the constitution of gastric microbiota in carcinogenesis, possibly resulting from a complex cross-talk between gastric microbiota and Helicobacter pylori. However, further studies are needed to elucidate the specific role (if any) of different microorganisms.
Authors: Miseker Abate; Elvira Vos; Mithat Gonen; Yelena Y Janjigian; Mark Schattner; Monika Laszkowska; Laura Tang; Steven B Maron; Daniel G Coit; Santosh Vardhana; Chad Vanderbilt; Vivian E Strong Journal: Ann Surg Date: 2022-07-13 Impact factor: 13.787
Authors: Ingeborg Klymiuk; Ceren Bilgilier; Alexander Stadlmann; Jakob Thannesberger; Marie-Theres Kastner; Christoph Högenauer; Andreas Püspök; Susanne Biowski-Frotz; Christiane Schrutka-Kölbl; Gerhard G Thallinger; Christoph Steininger Journal: Front Microbiol Date: 2017-12-14 Impact factor: 5.640
Authors: R Aarnoutse; J M P G M de Vos-Geelen; J Penders; E G Boerma; F A R M Warmerdam; B Goorts; S W M Olde Damink; Z Soons; S S M Rensen; M L Smidt Journal: Int J Colorectal Dis Date: 2017-04-25 Impact factor: 2.571