Literature DB >> 27600038

Endoperoxide Drug Cross-Resistance Patterns for Plasmodium falciparum Exhibiting an Artemisinin Delayed-Clearance Phenotype.

A Siriwardana1, K Iyengar1, P D Roepe2.   

Abstract

The ring-stage susceptibility assay was modified to quantify the susceptibilities of multiple strains of control and delayed-clearance phenotype (DCP) Plasmodium falciparum strains to seven endoperoxide antimalarial drugs. The susceptibility of all of the DCP lines to six of the drugs was lower than that of the controls. In contrast, DCP parasites did not show reduced susceptibility to the synthetic endoperoxide drug OZ439. These data show that it is possible to circumvent emerging artemisinin resistance with a modified endoperoxide drug.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27600038      PMCID： PMC5075116          DOI： 10.1128/AAC.00857-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  35 in total

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Journal:  Am J Trop Med Hyg       Date:  1994-12       Impact factor: 2.345

7.  Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria.

Authors:  P Teja-Isavadharm; G Watt; C Eamsila; K Jongsakul; Q Li; G Keeratithakul; N Sirisopana; L Luesutthiviboon; T G Brewer; D E Kyle
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Authors:  Arjen M Dondorp; François Nosten; Poravuth Yi; Debashish Das; Aung Phae Phyo; Joel Tarning; Khin Maung Lwin; Frederic Ariey; Warunee Hanpithakpong; Sue J Lee; Pascal Ringwald; Kamolrat Silamut; Mallika Imwong; Kesinee Chotivanich; Pharath Lim; Trent Herdman; Sen Sam An; Shunmay Yeung; Pratap Singhasivanon; Nicholas P J Day; Niklas Lindegardh; Duong Socheat; Nicholas J White
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Journal:  N Engl J Med       Date:  2014-07-31       Impact factor: 91.245

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  13 in total

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3.  Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro.

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9.  New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum.

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10.  Role of Plasmodium falciparum Kelch 13 Protein Mutations in P. falciparum Populations from Northeastern Myanmar in Mediating Artemisinin Resistance.

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