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Literature DB >> 2759910

A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity.

Y S Zhen¹, X Y Ming, B Yu, T Otani, H Saito, Y Yamada.

Abstract

C-1027, a new macromolecular antitumor antibiotic produced by Streptomyces globisporus C-1027, showed extremely potent cytotoxicity toward cultured cancer cells. Compared in terms of IC50 values, antibiotic C-1027 showed much more potent cytotoxicity than doxorubicin, mitomycin C and neocarzinostatin. Spermatogonial assay, a prescreen for anticancer drugs, was highly sensitive for detection of C-1027. At tolerable doses, C-1027 exhibited marked inhibition on a panel of transplantable tumors in mice, which included leukemia L1210, P388, ascites hepatoma H22, sarcoma 180 and melanoma Harding-Passey.

Entities: Chemical Disease Species

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Year: 1989 PMID： 2759910 DOI： 10.7164/antibiotics.42.1294

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

20 in total

1. Mitotic cell death in BEL-7402 cells induced by enediyne antibiotic lidamycin is associated with centrosome overduplication.

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Journal: World J Gastroenterol Date: 2004-09-15 Impact factor: 5.742

2. Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein.

Authors: W Liu; B Shen
Journal: Antimicrob Agents Chemother Date: 2000-02 Impact factor: 5.191

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Journal: J Ind Microbiol Biotechnol Date: 2015-08-29 Impact factor: 3.346

4. The novel structure make LDM effectively remove CD123+ AML stem cells in combination with interleukin 3.

Authors: Yanjun Zhang; Rong Liu; Dongmei Fan; Rizan Shi; Ming Yang; Qingfang Miao; Zhao-Qun Deng; Jun Qian; Yongsu Zhen; Dongsheng Xiong; Jianxiang Wang
Journal: Cancer Biol Ther Date: 2015-07-17 Impact factor: 4.742

5. Synergy of enediyne antibiotic lidamycin and temozolomide in suppressing glioma growth with potentiated apoptosis induction.

Authors: Xing-Qi Li; Zhi-Gang Ouyang; Sheng-Hua Zhang; Hong Liu; Yue Shang; Yi Li; Yong-Su Zhen
Journal: J Neurooncol Date: 2014-05-20 Impact factor: 4.130

A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity.

1. Mitotic cell death in BEL-7402 cells induced by enediyne antibiotic lidamycin is associated with centrosome overduplication.

2. Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein.

3. Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.

4. The novel structure make LDM effectively remove CD123+ AML stem cells in combination with interleukin 3.

5. Synergy of enediyne antibiotic lidamycin and temozolomide in suppressing glioma growth with potentiated apoptosis induction.

6. Antitumor efficacy of lidamycin on hepatoma and active moiety of its molecule.

7. Pharmacokinetics of C-1027 in mice as determined by TCA-RA method.

8. C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells.

9. DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases.

10. Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027.