Literature DB >> 22748380

DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases.

Joanna Maria N San Pedro1, Terry A Beerman, Marc M Greenberg.   

Abstract

C1027 is a potent antitumor agent that damages DNA. It has the unusual ability to produce double strand breaks and interstrand cross-links (ICLs) intracellularly, which enable it to initiate concurrent ataxia-telangiestasia mutated (ATM) and Rad-3 related (ATR) independent damage responses. The latter form of damage is not well characterized. We have examined the effect of DNA sequence on C1027 reactivity and found it to be more diverse than previously thought. In addition, analysis of the chemical stability of ICLs suggests that they result from reaction with the deoxyribose ring on one strand but direct addition to a nucleobase on the opposite strand.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22748380      PMCID： PMC3406177          DOI： 10.1016/j.bmc.2012.06.004

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  32 in total

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  9 in total

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