Jérémie Botton1, Claire Philippat2, Antonia M Calafat3, Sophie Carles4, Marie-Aline Charles4, Rémy Slama2. 1. INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Team "Early Origin of the Child's Health and Development" (ORCHAD), Paris Descartes University, Paris, France; Univ. Paris-Sud, Université Paris-Saclay, Faculty of Pharmacy, F-92296, Châtenay-Malabry, France. Electronic address: jeremie.botton@inserm.fr. 2. Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Inserm, CNRS, University Grenoble-Alpes, IAB (Institute for Advanced Biosciences) research center, F-38000 Grenoble, France. 3. Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA, USA. 4. INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Team "Early Origin of the Child's Health and Development" (ORCHAD), Paris Descartes University, Paris, France; Paris-Descartes University, F-75005 Paris, France.
Abstract
OBJECTIVE: To study associations between prenatal exposure to phthalates and fetal and postnatal growth up to age 5 years in male offspring. METHODS: Eleven phthalate metabolites were quantified in spot maternal urine samples collected during gestation among 520 women of the EDEN mother-child cohort who gave birth to a boy. Fetal growth was assessed from repeated ultrasound measurements and measurements at birth. We used repeated measures of weight and height in the first 5 years of life to model individual postnatal growth trajectories. We estimated adjusted variations in pre and postnatal growth parameters associated with an interquartile range increase in ln-transformed phthalate metabolite concentrations. RESULTS: Monocarboxyisononyl phthalate (MCNP) was positively associated with femoral length during gestation and length at birth. High molecular weight phthalate metabolites were negatively associated with estimated fetal weight throughout pregnancy. Monoethyl phthalate (MEP) showed positive association with weight growth velocity from two to five years and with body mass index at five years (β=0.17kg/m2, 95% confidence interval, 0.04, 0.30). CONCLUSIONS: We highlighted associations between gestational exposure to some phthalates and growth in boys. The positive association between MEP and postnatal growth in boys was also reported in several previous human studies.
OBJECTIVE: To study associations between prenatal exposure to phthalates and fetal and postnatal growth up to age 5 years in male offspring. METHODS: Eleven phthalate metabolites were quantified in spot maternal urine samples collected during gestation among 520 women of the EDEN mother-child cohort who gave birth to a boy. Fetal growth was assessed from repeated ultrasound measurements and measurements at birth. We used repeated measures of weight and height in the first 5 years of life to model individual postnatal growth trajectories. We estimated adjusted variations in pre and postnatal growth parameters associated with an interquartile range increase in ln-transformed phthalate metabolite concentrations. RESULTS:Monocarboxyisononyl phthalate (MCNP) was positively associated with femoral length during gestation and length at birth. High molecular weight phthalate metabolites were negatively associated with estimated fetal weight throughout pregnancy. Monoethyl phthalate (MEP) showed positive association with weight growth velocity from two to five years and with body mass index at five years (β=0.17kg/m2, 95% confidence interval, 0.04, 0.30). CONCLUSIONS: We highlighted associations between gestational exposure to some phthalates and growth in boys. The positive association between MEP and postnatal growth in boys was also reported in several previous human studies.
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