Kaori Kikunaga1, Kenji Ishikura2,3, Chikako Terano1, Mai Sato4, Fumiyo Komaki5, Yuko Hamasaki6, Satoshi Sasaki7, Kazumoto Iijima8, Norishige Yoshikawa9, Koichi Nakanishi9, Hitoshi Nakazato10, Takeshi Matsuyama11, Takashi Ando12, Shuichi Ito4,13, Masataka Honda1. 1. Department of Nephrology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan. 2. Department of Nephrology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan. kenzo@ii.e-mansion.com. 3. Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. kenzo@ii.e-mansion.com. 4. Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. 5. Department of Health and Welfare Bureau, Health and Welfare Bureau Health Center of Kawasaki City, Kanagawa, Japan. 6. Department of Pediatric Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan. 7. Department of Pediatrics, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan. 8. Department of Pediatrics, Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan. 9. Clinical Research Center, Wakayama Medical University, Wakayama, Japan. 10. Department of Pediatrics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. 11. Department of Pediatrics, Fussa Hospital, Tokyo, Japan. 12. Japan Clinical Research Support Unit, Tokyo, Japan. 13. Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Abstract
BACKGROUND: Little is known regarding the epidemiology of idiopathic nephrotic syndrome (INS) in East Asia. Previous studies have suggested higher incidence of INS in Asian children, though decreasing trend of its incidence has also been shown. METHODS: We conducted a nationwide study of Japanese children aged 6 months to 15 years with INS. Children who were newly diagnosed with INS between 1 January 2010 and 31 December 2012 were eligible. Children with congenital nephrotic syndrome or nephrotic syndrome secondary to nephritis were excluded. RESULTS: A total of 2099 children were initially diagnosed with INS and were followed for up to 4 years. The estimated incidence of INS was 6.49 cases/100,000 children per year, without clear correlation with geographical region. The male:female ratio was 1.9 and approximately 50 % of children were <5 years old at diagnosis. During the 1-4 years follow-up, 32.7 % developed frequently relapsing nephrotic syndrome and steroid-dependent nephrotic syndrome. CONCLUSIONS: Based on our nationwide survey, the incidence of INS in Japanese children is approximately 3-4 times higher than that in Caucasians. However, the male:female ratio and the age at onset were similar to those in previous studies. We are now planning a prospective cohort study to examine the course of INS in Japan.
BACKGROUND: Little is known regarding the epidemiology of idiopathic nephrotic syndrome (INS) in East Asia. Previous studies have suggested higher incidence of INS in Asian children, though decreasing trend of its incidence has also been shown. METHODS: We conducted a nationwide study of Japanese children aged 6 months to 15 years with INS. Children who were newly diagnosed with INS between 1 January 2010 and 31 December 2012 were eligible. Children with congenital nephrotic syndrome or nephrotic syndrome secondary to nephritis were excluded. RESULTS: A total of 2099 children were initially diagnosed with INS and were followed for up to 4 years. The estimated incidence of INS was 6.49 cases/100,000 children per year, without clear correlation with geographical region. The male:female ratio was 1.9 and approximately 50 % of children were <5 years old at diagnosis. During the 1-4 years follow-up, 32.7 % developed frequently relapsing nephrotic syndrome and steroid-dependent nephrotic syndrome. CONCLUSIONS: Based on our nationwide survey, the incidence of INS in Japanese children is approximately 3-4 times higher than that in Caucasians. However, the male:female ratio and the age at onset were similar to those in previous studies. We are now planning a prospective cohort study to examine the course of INS in Japan.
Authors: Loubna El Bakkali; Robert Rodrigues Pereira; Dirk J Kuik; Johannes C F Ket; Joanna A E van Wijk Journal: Pediatr Nephrol Date: 2011-05-01 Impact factor: 3.714
Authors: Ingo Franke; Malik Aydin; Corinna Elke Llamas Lopez; Lisa Kurylowicz; Rainer Ganschow; Michael Lentze; Mark Born Journal: Clin Exp Nephrol Date: 2017-06-22 Impact factor: 2.801
Authors: Hai-Yun Geng; Chao-Ying Chen; Juan Tu; Hua-Rong Li; Pei-Wei DU; Hua Xia; Xiao-Ning Yu Journal: Zhongguo Dang Dai Er Ke Za Zhi Date: 2022-08-15