Ingo Franke1, Malik Aydin2,3,4, Corinna Elke Llamas Lopez1, Lisa Kurylowicz1, Rainer Ganschow1, Michael Lentze1, Mark Born5. 1. Department of General Paediatrics, University Children's Hospital Bonn, Bonn, Germany. 2. Department of General Paediatrics, University Children's Hospital Bonn, Bonn, Germany. malik.aydin@uni-wh.de. 3. Centre of Biomedical Education and Research, Helios University Children's Hospital Wuppertal, University of Witten/Herdecke, Witten, Germany. malik.aydin@uni-wh.de. 4. Helios University Children's Hospital Wuppertal, University of Witten/Herdecke, Heusnerstr. 40, 42283, Wuppertal, Germany. malik.aydin@uni-wh.de. 5. Department of Radiology, Paediatric Radiology, University of Bonn, Bonn, Germany.
Abstract
BACKGROUND: The incidence of childhood nephrotic syndrome (NS) in Germany is not well known. METHODS: An ESPED-based nationwide collection of epidemiological data of children in 2005 and 2006. RESULT: The mean age of NS at onset was 5.5 ± 3.7 years. The gender ratio of boys to girls was 1.8:1. The average length of stay was 15.5 ± 11.2 days, with younger children remaining significantly longer in hospital. Steroid-resistance was more common in children ≥8 years (p = 0.023). Focal-segmental glomerulosclerosis (FSGS) was more common in children >10 years (p = 0.029). The ratio of males to females with FSGS was 1:1.9, thus the FSGS risk for girls at onset was 3.3-times greater. Considering the available data, the incidence of NS in Germany is 1.2/100,000 in the population <18 years, of which 1.0/100,000 are steroid-sensitive. CONCLUSION: Compared with international data, which primarily focused on regional and small populations, this is the largest study about the incidence of the childhood NS.
BACKGROUND: The incidence of childhood nephrotic syndrome (NS) in Germany is not well known. METHODS: An ESPED-based nationwide collection of epidemiological data of children in 2005 and 2006. RESULT: The mean age of NS at onset was 5.5 ± 3.7 years. The gender ratio of boys to girls was 1.8:1. The average length of stay was 15.5 ± 11.2 days, with younger children remaining significantly longer in hospital. Steroid-resistance was more common in children ≥8 years (p = 0.023). Focal-segmental glomerulosclerosis (FSGS) was more common in children >10 years (p = 0.029). The ratio of males to females with FSGS was 1:1.9, thus the FSGS risk for girls at onset was 3.3-times greater. Considering the available data, the incidence of NS in Germany is 1.2/100,000 in the population <18 years, of which 1.0/100,000 are steroid-sensitive. CONCLUSION: Compared with international data, which primarily focused on regional and small populations, this is the largest study about the incidence of the childhood NS.
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